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Overview

Uniprot IDA0A024R1A3
Protein NameUbiquitin-like modifier-activating enzyme 1
Gene Name-
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
830 DSRLEELKATLPSPD
911 LVCLELYKVVQGHRQ

Function

Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites

Protein Sequence

10 MSSSPLSKKR 20 RVSGPDPKPG 30 SNCSPAQSVL 40 SEVPSVPTNG 50 MAKNGSEADI 60 DEGLYSRQLY 70 VLGHEAMKRL 80 QTSSVLVSGL 90 RGLGVEIAKN 100 IILGGVKAVT 110 LHDQGTAQWA 120 DLSSQFYLRE 130 EDIGKNRAEV 140 SQPRLAELNS 150 YVPVTAYTGP 160 LVEDFLSGFQ 170 VVVLTNTPLE 180 DQLRVGEFCH 190 NRGIKLVVAD 200 TRGLFGQLFC 210 DFGEEMILTD 220 SNGEQPLSAM 230 VSMVTKDNPG 240 VVTCLDEARH 250 GFESGDFVSF 260 SEVQGMVELN 270 GNQPMEIKVL 280 GPYTFSICDT 290 SNFSDYIRGG 300 IVSQVKVPKK 310 ISFKSLVASL 320 AEPDFVVTDF 330 AKFSRPAQLH 340 IGFQALHQFC 350 AQHGRPPRPR 360 NEEDAAELVA 370 LAQAVNARAL 380 PAVQQNNLDE 390 DLIRKLAYVA 400 AGDLAPINAF 410 IGGLAAQEVM 420 KACSGKFMPI 430 MQWLYFDALE 440 CLPEDKEVLT 450 EDKCLQRQNR 460 YDGQVAVFGS 470 DLQEKLGKQK 480 YFLVGAGAIG 490 CELLKNFAMI 500 GLGCGEGGEI 510 IVTDMDTIEK 520 SNLNRQFLFR 530 PWDVTKLKSD 540 TAAAAVRQMN 550 PHIRVTSHQN 560 RVGPDTERIY 570 DDDFFQNLDG 580 VANALDNVDA 590 RMYMDRRCVY 600 YRKPLLESGT 610 LGTKGNVQVV 620 IPFLTESYSS 630 SQDPPEKSIP 640 ICTLKNFPNA 650 IEHTLQWARD 660 EFEGLFKQPA 670 ENVNQYLTDP 680 KFVERTLRLA 690 GTQPLEVLEA 700 VQRSLVLQRP 710 QTWADCVTWA 720 CHHWHTQYSN 730 NIRQLLHNFP 740 PDQLTSSGAP 750 FWSGPKRCPH 760 PLTFDVNNPL 770 HLDYVMAAAN 780 LFAQTYGLTG 790 SQDRAAVATF 800 LQSVQVPEFT 810 PKSGVKIHVS 820 DQELQSANAS 830 VDDSRLEELK 840 ATLPSPDKLP 850 GFKMYPIDFE 860 KDDDSNFHMD 870 FIVAASNLRA 880 ENYDIPSADR 890 HKSKLIAGKI 900 IPAIATTTAA 910 VVGLVCLELY 920 KVVQGHRQLD 930 SYKNGFLNLA 940 LPFFGFSEPL 950 AAPRHQYYNQ 960 EWTLWDRFEV 970 QGLQPNGEEM 980 TLKQFLDYFK 990 TEHKLEITML 1000 SQGVSMLYSF 1010 FMPAAKLKER 1020 LDQPMTEIVS 1030 RVSKRKLGRH 1040 VRALVLELCC 1050 NDESGEDVEV PYVRYTIR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004839 ubiquitin activating enzyme activity

Reference

PMID: N/A