Search Results
Overview
| Uniprot ID | A0A024R6M6 |
|---|---|
| Protein Name | BAG family molecular chaperone regulator 5 |
| Gene Name | BAG5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 324 | LDEVSLEKNPCIREA |
Function
Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding. Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN
Protein Sequence
10
MDMGNQHPSI
20
SRLQEIQKEV
30
KSVEQQVIGF
40
SGLSDDKNYK
50
KLERILTKQL
60
FEIDSVDTEG
70
KGDIQQARKR
80
AAQETERLLK
90
ELEQNANHPH
100
RIEIQNIFEE
110
AQSLVREKIV
120
PFYNGGNCVT
130
DEFEEGIQDI
140
ILRLTHVKTG
150
GKISLRKARY
160
HTLTKICAVQ
170
EIIEDCMKKQ
180
PSLPLSEDAH
190
PSVAKINFVM
200
CEVNKARGVL
210
IALLMGVNNN
220
ETCRHLSCVL
230
SGLIADLDAL
240
DVCGRTEIRN
250
YRREVVEDIN
260
KLLKYLDLEE
270
EADTTKAFDL
280
RQNHSILKIE
290
KVLKRMREIK
300
NELLQAQNPS
310
ELYLSSKTEL
320
QGLIGQLDEV
330
SLEKNPCIRE
340
ARRRAVIEVQ
350
TLITYIDLKE
360
ALEKRKLFAC
370
EEHPSHKAVW
380
NVLGNLSEIQ
390
GEVLSFDGNR
400
TDKNYIRLEE
410
LLTKQLLALD
420
AVDPQGEEKC
430
KAARKQAVRL
440
AQNILSYLDL
KSDEWEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030314 | junctional membrane complex |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
| Biological Process | GO:0090083 | regulation of inclusion body assembly |
Reference
PMID: N/A