Search Results

Overview

Uniprot IDA0A075B730
Protein NameEpiplakin
Gene NameEPPK1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1865 LSTLECVKPYLEGSG

Function

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization

Protein Sequence

10 MAATLGAGTP 20 PRPQARSIAG 30 VYVEASGQAQ 40 SVYAAMEQGL 50 LPAGLGQALL 60 EAQAATGGLV 70 DLARGQLLPV 80 SKALQQGLVG 90 LELKEKLLAA 100 ERATTGYPDP 110 YGGEKLALFQ 120 AIGKEVVDRA 130 LGQSWLEVQL 140 ATGGLVDPAQ 150 GVLVAPEPAC 160 HQGLLDRETW 170 HKLSELEPGT 180 GDLRFLDPNT 190 LERLTYHQLL 200 ERCVRAPGSG 210 LALLPLKITF 220 RSMGGAVSAA 230 ELLEVGILDE 240 QAVQGLREGR 250 LAAVDVSARA 260 EVRRYLEGTG 270 SVAGVVLLPE 280 GHKKSFFQAA 290 TEHLLPMGTA 300 LPLLEAQAAT 310 HTLVDPITGQ 320 RLWVDEAVRA 330 GLVSPELHEQ 340 LLVAEQAVTG 350 HHDPFSGSQI 360 PLFQAMKKGL 370 VDRPLALRLL 380 DAQLATGGLV 390 CPARRLRLPL 400 EAALRCGCLD 410 EDTQRQLSQA 420 GSFSDGTHGG 430 LRYEQLLALC 440 VTDPETGLAF 450 LPLSGGPRGG 460 EPQGPPFIKY 470 STRQALSTAT 480 ATVSVGKFRG 490 RPVSLWELLF 500 SEAISSEQRA 510 MLAQQYQEGT 520 LSVEKLAAKL 530 SATLEQAAAT 540 ARVTFSGLRD 550 TVTPGELLKA 560 EIIDQDLYER 570 LEHGQATAKD 580 VGSLASVQRY 590 LQGTGCIAGL 600 LLPGSQERLS 610 IYEARCKGLL 620 RPGTALILLE 630 AQAATGFIID 640 PKANKGHSVE 650 EALRAAVIGP 660 DVFAKLLSAE 670 RAVTGYTDPY 680 TGQQISLFQA 690 MQKGLIVREH 700 GIRLLEAQIA 710 TGGVIDPVHS 720 HRVPVDVAYR 730 RGYFDQMLNL 740 ILLDPSDDTK 750 GFFDPNTHEN 760 LTYLQLLERC 770 VRDPETGLYL 780 LPLSSTQSPL 790 VDSATQQAFQ 800 NLLLSVKYGR 810 FQGQRVSAWE 820 LINSEYFSEG 830 RRRQLLRRYR 840 QREVTLGQVA 850 KLLEAETQRQ 860 ADIMLPALRS 870 RVTVHQLLEA 880 GIIDQQLLDQ 890 VLAGTISPEA 900 LLLMDGVRRY 910 LCGLGAVGGV 920 RLLPSGQRLS 930 LYQAMRQKLL 940 GPRVALALLE 950 AQAATGTIMD 960 PHSPESLSVD 970 EAVRRGVVGP 980 ELYGRLKRAE 990 GAIAGFRDPF 1000 SGKQVSVFQA 1010 MKKGLIPWEQ 1020 AARLLEAQVA 1030 TGGIIDPTSH 1040 HHLPMPVAIQ 1050 RGYVDQEMET 1060 ALSSSSETFP 1070 TPDGQGRTSY 1080 AQLLEECPRD 1090 ETSGLHLLPL 1100 PESAPALPTE 1110 EQVQRSLQAV 1120 PGAKDGTSLW 1130 DLLSSCHFTE 1140 EQRRGLLEDV 1150 QEGRTTVPQL 1160 LASVQRWVQE 1170 TKLLAQARVM 1180 VPGPRGEVPA 1190 VWLLDAGIIT 1200 QETLEALAQG 1210 TQSPAQVAEQ 1220 PAVKACLWGT 1230 GCVAGVLLQP 1240 SGAKASIAQA 1250 VRDGLLPTGL 1260 GQRLLEAQVA 1270 SGFLVDPLNN 1280 QRLSVEDAVK 1290 VGLVGRELSE 1300 QLGQAERAAA 1310 GYPDPYSRAS 1320 LSLWQAMEKG 1330 LVPQNEGLPL 1340 LQVQLATGGV 1350 VDPVHGVHLP 1360 QAAACRLGLL 1370 DTQTSQVLTA 1380 VDKDNKFFFD 1390 PSARDQVTYQ 1400 QLRERCVCDS 1410 ETGLLLLPLP 1420 SDTVLEVDDH 1430 TAVALRAMKV 1440 PVSTGRFKGC 1450 SVSLWDLLLS 1460 EYVGADKRRE 1470 LVALCRSGRA 1480 AALRQVVSAV 1490 TTLVEAAERQ 1500 PLQATFRGLR 1510 KQVSARDLFR 1520 AQLISRKTLD 1530 ELSQGTTTVK 1540 EVAEMDSVKR 1550 SLEGGNFIAG 1560 VLIQGTQERM 1570 SIPEALRRHI 1580 LRPGTALVLL 1590 EAQAATGFII 1600 DPVENRKLTV 1610 EEAFKAGMFG 1620 KETYVKLLSA 1630 ERAVTGYTDP 1640 YTGQQISLFQ 1650 AMQKDLIVRE 1660 HGIRLLEAQI 1670 ATGGIIDPVH 1680 SHRVPVDVAY 1690 RCGYFDEEMN 1700 RILADPSDDT 1710 KGFFDPNTHE 1720 NLTYLQLLER 1730 CVEDPETGLY 1740 LLQIIKKGEN 1750 YVYINEATRH 1760 VLQSRTAKMR 1770 VGRFADQVVS 1780 FWDLLSSPYF 1790 TEDRKRELIQ 1800 EYGAQSGGLE 1810 KLLEIITTTI 1820 EETETQNQGI 1830 KVAAIRGEVT 1840 AADLFNSRVI 1850 DQKTLHTLRV 1860 GRTGGQALST 1870 LECVKPYLEG 1880 SGCIAGVTVP 1890 STREVMSLHE 1900 ASRKELIPAA 1910 FATWLLEAQA 1920 ATGFLLDPCT 1930 RQKLSVDEAV 1940 DVGLVNEELR 1950 ERLLKAERAA 1960 TGYRDPATGD 1970 TIPLFQAMQK 1980 QLIEKAEALR 1990 LLEVQVATGG 2000 VIDPQHHHRL 2010 PLETAYRRGC 2020 LHKDIYALIS 2030 DQKHMRKRFV 2040 DPNTQEKVSY 2050 RELQERCRPQ 2060 EDTGWLLFPV 2070 NKAARDSEHI 2080 DDETRRALEA 2090 EQVEITVGRF 2100 RGQKPTLWAL 2110 LNSEYVTEEK 2120 KLQLVRMYRT 2130 HTRRALQTVA 2140 QLILELIEKQ 2150 ETSNKHLWFQ 2160 GIRRQITASE 2170 LLSSAIITEE 2180 MLQDLETGRS 2190 TTQELMEDDR 2200 VKRYLEGTSC 2210 IAGVLVPAKD 2220 QPGRQEKMSI 2230 YQAMWKGVLR 2240 PGTALVLLEA 2250 QAATGFVIDP 2260 VRNLRLSVEE 2270 AVAAGVVGGE 2280 IQEKLLSAER 2290 AVTGYTDPYT 2300 GQQISLFQAM 2310 QKDLIVREHG 2320 IRLLEAQIAT 2330 GGVIDPVHSH 2340 RVPVDVAYRR 2350 GYFDEEMNRV 2360 LADPSDDTKG 2370 FFDPNTHENL 2380 TYVQLLRRCV 2390 PDPDTGLYML 2400 QLAGRGSAVH 2410 QLSEELRCAL 2420 RDARVTPGSG 2430 ALQGQSVSVW 2440 ELLFYREVSE 2450 DRRQDLLSRY 2460 RAGTLTVEEL 2470 GATLTSLLAQ 2480 AQAQARAEAE 2490 AGSPRPDPRE 2500 ALRAATMEVK 2510 VGRLRGRAVP 2520 VWDVLASGYV 2530 SRAAREELLA 2540 EFGSGTLDLP 2550 ALTRRLTAII 2560 EEAEEAPGAR 2570 PQLQDAWRGP 2580 REPGPAGRGD 2590 GDSGRSQREG 2600 QGEGETQEAA 2610 AAAAAAAARR 2620 QEQTLRDATM 2630 EVQRGQFQGR 2640 PVSVWDVLFS 2650 SYLSEARRDE 2660 LLAQHAAGAL 2670 GLPDLVAVLT 2680 RVIEETEERL 2690 SKVSFRGLRR 2700 QVSASELHTS 2710 GILGPETLRD 2720 LAQGTKTLQE 2730 VTEMDSVKRY 2740 LEGTSCIAGV 2750 LVPAKDQPGR 2760 QEKMSIYQAM 2770 WKGVLRPGTA 2780 LVLLEAQAAT 2790 GFVIDPVRNL 2800 RLSVEEAVAA 2810 GVVGGEIQEK 2820 LLSAERAVTG 2830 YTDPYTGQQI 2840 SLFQAMQKDL 2850 IVREHGIRLL 2860 EAQIATGGVI 2870 DPVHSHRVPV 2880 DVAYQRGYFD 2890 EEMNRVLADP 2900 SDDTKGFFDP 2910 NTHENLTYVQ 2920 LLRRCVPDPD 2930 TGLYMLQLAG 2940 RGSAVHQLSE 2950 ELRCALRDAR 2960 VTPGSGALQG 2970 QSVSVWELLF 2980 YREVSEDRRQ 2990 DLLSRYRAGT 3000 LTVEELGATL 3010 TSLLAQAQAQ 3020 ARAEAEAGSP 3030 RPDPREALRA 3040 ATMEVKVGRL 3050 RGRAVPVWDV 3060 LASGYVSRAA 3070 REELLAEFGS 3080 GTLDLPALTR 3090 RLTAIIEEAE 3100 EAPGARPQLQ 3110 DAWRGPREPG 3120 PAGRGDGDSG 3130 RSQREGQGEG 3140 ETQEAAAAAR 3150 RQEQTLRDAT 3160 MEVQRGQFQG 3170 RPVSVWDVLF 3180 SSYLSEARRD 3190 ELLAQHAAGA 3200 LGLPDLVAVL 3210 TRVIEETEER 3220 LSKVSFRGLR 3230 CQVSASELHT 3240 SGILGPETLR 3250 DLAQGTKTLQ 3260 EVTEMDSVKR 3270 YLEGTSCIAG 3280 VLVPAKDQPG 3290 RQEKMSIYQA 3300 MWKGVLRPGT 3310 ALVLLEAQAA 3320 TGFVIDPVRN 3330 LRLSVEEAVA 3340 AGVVGGEIQE 3350 KLLSAERAVT 3360 GYTDPYTGQQ 3370 ISLFQAMQKD 3380 LIVREHGIRL 3390 LEAQIATGGV 3400 IDPVHSHRVP 3410 VDVAYRRGYF 3420 DEEMNRVLAD 3430 PSDDTKGFFD 3440 PNTHENLTYV 3450 QLLRRCVPDP 3460 DTGLYMLQLA 3470 GRGSAVHQLS 3480 EELRCALRDA 3490 RVTPGSGALQ 3500 GQSVSVWELL 3510 FYREVSEDRR 3520 QDLLSRYRAG 3530 TLTVEELGAT 3540 LTSLLAQAQA 3550 QARAEAEAGS 3560 PRPDPREALR 3570 AATMEVKVGR 3580 LRGRAVPVWD 3590 VLASGYVSRA 3600 AREELLAEFG 3610 SGTLDLPALT 3620 RRLTAIIEEA 3630 EEAPGARPQL 3640 QDAWRGPREP 3650 GPAGRGDGDS 3660 GRSQREGQGE 3670 GETQEAAAAT 3680 AAARRQEQTL 3690 RDATMEVQRG 3700 QFQGRPVSVW 3710 DVLFSSYLSE 3720 ARRDELLAQH 3730 AAGALGLPDL 3740 VAVLTRVIEE 3750 TEERLSKVSF 3760 RGLRRQVSAS 3770 ELHTSGILGP 3780 ETLRDLAQGT 3790 KTLQEVTEMD 3800 SVKRYLEGTS 3810 CIAGVLVPAK 3820 DQPGRQEKMS 3830 IYQAMWKGVL 3840 RPGTALVLLE 3850 AQAATGFVID 3860 PVRNLRLSVE 3870 EAVAAGVVGG 3880 EIQEKLLSAE 3890 RAVTGYTDPY 3900 TGQQISLFQA 3910 MQKDLIVREH 3920 GIRLLEAQIA 3930 TGGVIDPVHS 3940 HRVPVDVAYR 3950 RGYFDEEMNR 3960 VLADPSDDTK 3970 GFFDPNTHEN 3980 LTYVQLLRRC 3990 VPDPDTGLYM 4000 LQLAGRGSAV 4010 HQLSEELRCA 4020 LRDARVTPGS 4030 GALQGQSVSV 4040 WELLFYREVS 4050 EDRRQDLLSR 4060 YRAGTLTVEE 4070 LGATLTSLLA 4080 QAQAQARAEA 4090 EAGSPRPDPR 4100 EALRAATMEV 4110 KVGRLRGRAV 4120 PVWDVLASGY 4130 VSRAAREELL 4140 AEFGSGTLDL 4150 PALTRRLTAI 4160 IEEAEEAPGA 4170 RPQLQDAWRG 4180 PREPGPAGRG 4190 DGDSGRSQRE 4200 GQGEGETQEA 4210 AAATAAARRQ 4220 EQTLRDATME 4230 VQRGQFQGRP 4240 VSVWDVLFSS 4250 YLSEARRDEL 4260 LAQHAAGALG 4270 LPDLVAVLTR 4280 VIEETEERLS 4290 KVSFRGLRRQ 4300 VSASELHTSG 4310 ILGPETLRDL 4320 AQGTKTLQEV 4330 TEMDSVKRYL 4340 EGTSCIAGVL 4350 VPAKDQPGHQ 4360 EKMSIYQAMW 4370 KGVLRPGTAL 4380 VLLEAQAATG 4390 FVIDPVRNLR 4400 LSVEEAVAAG 4410 VVGGEIQEKL 4420 LSAERAVTGY 4430 TDPYTGQQIS 4440 LFQAMQKDLI 4450 VREHGIRLLE 4460 AQIATGGVID 4470 PVHSHRVPVD 4480 VAYRRGYFDE 4490 EMNRVLAHPS 4500 DDTKGFFDPN 4510 THENLTYVQL 4520 LRRCVPDPDT 4530 GLYMLQLAGR 4540 GSAVHQLSEE 4550 LRCALRDARV 4560 MPGSGALQGQ 4570 SVSVWELLFY 4580 REVSEDRRQD 4590 LLSRYRAGTL 4600 TVEELGATLT 4610 SLLAQAQAQA 4620 RAEAEAEAGS 4630 PRPDPREALR 4640 AATMEVKVGR 4650 LRGRAVPVWD 4660 VLASGYVSGA 4670 AREELLAEFG 4680 SGTLDLPALT 4690 RRLTAIIEEA 4700 EEAPGARPQL 4710 QDAWRGPREP 4720 GPAGRGDGDS 4730 GRSQREGQGE 4740 GETQEAAAAA 4750 RRQEQTLRDA 4760 TMEVQRGQFQ 4770 GRPVSVWDVL 4780 FSSYLSEAHR 4790 DELLAQHAAG 4800 ALGLPDLVAV 4810 LTRVIEETEE 4820 RLSKVSFRGL 4830 RRQVSASELH 4840 TSGILGPETL 4850 RDLAQGTKTL 4860 QEVTEMDSVK 4870 RYLEGTSCIA 4880 GVLVPAKDQP 4890 GRQEKMSIYQ 4900 AMWKGVLRPG 4910 TALVLLEAQA 4920 ATGFVIDPVR 4930 NLRLSVEEAV 4940 AAGVVGGEIQ 4950 EKLLSAERAV 4960 TGYTDPYTGQ 4970 QISLFQAMQK 4980 DLIVREHGIR 4990 LLEAQIATGG 5000 VIDPVHSHRV 5010 PVDVAYRRGY 5020 FDEEMNRVLA 5030 DPSDDTKGFF 5040 DPNTHENLTY 5050 LQLLQRATLD 5060 PETGLLFLSL SLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016327 apicolateral plasma membrane
Cellular Component GO:0016323 basolateral plasma membrane
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0042995 cell projection
Cellular Component GO:0030056 hemidesmosome
Cellular Component GO:0045111 intermediate filament cytoskeleton
Molecular Function GO:0019215 intermediate filament binding
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:0050680 negative regulation of epithelial cell proliferation
Biological Process GO:0061045 negative regulation of wound healing
Biological Process GO:0042060 wound healing

Reference

PMID: N/A