Overview
| Uniprot ID | A0A075B730 |
| Protein Name | Epiplakin |
| Gene Name | EPPK1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 1865 |
LSTLECVKPYLEGSG |
Function
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization
Protein Sequence
10
MAATLGAGTP
20
PRPQARSIAG
30
VYVEASGQAQ
40
SVYAAMEQGL
50
LPAGLGQALL
60
EAQAATGGLV
70
DLARGQLLPV
80
SKALQQGLVG
90
LELKEKLLAA
100
ERATTGYPDP
110
YGGEKLALFQ
120
AIGKEVVDRA
130
LGQSWLEVQL
140
ATGGLVDPAQ
150
GVLVAPEPAC
160
HQGLLDRETW
170
HKLSELEPGT
180
GDLRFLDPNT
190
LERLTYHQLL
200
ERCVRAPGSG
210
LALLPLKITF
220
RSMGGAVSAA
230
ELLEVGILDE
240
QAVQGLREGR
250
LAAVDVSARA
260
EVRRYLEGTG
270
SVAGVVLLPE
280
GHKKSFFQAA
290
TEHLLPMGTA
300
LPLLEAQAAT
310
HTLVDPITGQ
320
RLWVDEAVRA
330
GLVSPELHEQ
340
LLVAEQAVTG
350
HHDPFSGSQI
360
PLFQAMKKGL
370
VDRPLALRLL
380
DAQLATGGLV
390
CPARRLRLPL
400
EAALRCGCLD
410
EDTQRQLSQA
420
GSFSDGTHGG
430
LRYEQLLALC
440
VTDPETGLAF
450
LPLSGGPRGG
460
EPQGPPFIKY
470
STRQALSTAT
480
ATVSVGKFRG
490
RPVSLWELLF
500
SEAISSEQRA
510
MLAQQYQEGT
520
LSVEKLAAKL
530
SATLEQAAAT
540
ARVTFSGLRD
550
TVTPGELLKA
560
EIIDQDLYER
570
LEHGQATAKD
580
VGSLASVQRY
590
LQGTGCIAGL
600
LLPGSQERLS
610
IYEARCKGLL
620
RPGTALILLE
630
AQAATGFIID
640
PKANKGHSVE
650
EALRAAVIGP
660
DVFAKLLSAE
670
RAVTGYTDPY
680
TGQQISLFQA
690
MQKGLIVREH
700
GIRLLEAQIA
710
TGGVIDPVHS
720
HRVPVDVAYR
730
RGYFDQMLNL
740
ILLDPSDDTK
750
GFFDPNTHEN
760
LTYLQLLERC
770
VRDPETGLYL
780
LPLSSTQSPL
790
VDSATQQAFQ
800
NLLLSVKYGR
810
FQGQRVSAWE
820
LINSEYFSEG
830
RRRQLLRRYR
840
QREVTLGQVA
850
KLLEAETQRQ
860
ADIMLPALRS
870
RVTVHQLLEA
880
GIIDQQLLDQ
890
VLAGTISPEA
900
LLLMDGVRRY
910
LCGLGAVGGV
920
RLLPSGQRLS
930
LYQAMRQKLL
940
GPRVALALLE
950
AQAATGTIMD
960
PHSPESLSVD
970
EAVRRGVVGP
980
ELYGRLKRAE
990
GAIAGFRDPF
1000
SGKQVSVFQA
1010
MKKGLIPWEQ
1020
AARLLEAQVA
1030
TGGIIDPTSH
1040
HHLPMPVAIQ
1050
RGYVDQEMET
1060
ALSSSSETFP
1070
TPDGQGRTSY
1080
AQLLEECPRD
1090
ETSGLHLLPL
1100
PESAPALPTE
1110
EQVQRSLQAV
1120
PGAKDGTSLW
1130
DLLSSCHFTE
1140
EQRRGLLEDV
1150
QEGRTTVPQL
1160
LASVQRWVQE
1170
TKLLAQARVM
1180
VPGPRGEVPA
1190
VWLLDAGIIT
1200
QETLEALAQG
1210
TQSPAQVAEQ
1220
PAVKACLWGT
1230
GCVAGVLLQP
1240
SGAKASIAQA
1250
VRDGLLPTGL
1260
GQRLLEAQVA
1270
SGFLVDPLNN
1280
QRLSVEDAVK
1290
VGLVGRELSE
1300
QLGQAERAAA
1310
GYPDPYSRAS
1320
LSLWQAMEKG
1330
LVPQNEGLPL
1340
LQVQLATGGV
1350
VDPVHGVHLP
1360
QAAACRLGLL
1370
DTQTSQVLTA
1380
VDKDNKFFFD
1390
PSARDQVTYQ
1400
QLRERCVCDS
1410
ETGLLLLPLP
1420
SDTVLEVDDH
1430
TAVALRAMKV
1440
PVSTGRFKGC
1450
SVSLWDLLLS
1460
EYVGADKRRE
1470
LVALCRSGRA
1480
AALRQVVSAV
1490
TTLVEAAERQ
1500
PLQATFRGLR
1510
KQVSARDLFR
1520
AQLISRKTLD
1530
ELSQGTTTVK
1540
EVAEMDSVKR
1550
SLEGGNFIAG
1560
VLIQGTQERM
1570
SIPEALRRHI
1580
LRPGTALVLL
1590
EAQAATGFII
1600
DPVENRKLTV
1610
EEAFKAGMFG
1620
KETYVKLLSA
1630
ERAVTGYTDP
1640
YTGQQISLFQ
1650
AMQKDLIVRE
1660
HGIRLLEAQI
1670
ATGGIIDPVH
1680
SHRVPVDVAY
1690
RCGYFDEEMN
1700
RILADPSDDT
1710
KGFFDPNTHE
1720
NLTYLQLLER
1730
CVEDPETGLY
1740
LLQIIKKGEN
1750
YVYINEATRH
1760
VLQSRTAKMR
1770
VGRFADQVVS
1780
FWDLLSSPYF
1790
TEDRKRELIQ
1800
EYGAQSGGLE
1810
KLLEIITTTI
1820
EETETQNQGI
1830
KVAAIRGEVT
1840
AADLFNSRVI
1850
DQKTLHTLRV
1860
GRTGGQALST
1870
LECVKPYLEG
1880
SGCIAGVTVP
1890
STREVMSLHE
1900
ASRKELIPAA
1910
FATWLLEAQA
1920
ATGFLLDPCT
1930
RQKLSVDEAV
1940
DVGLVNEELR
1950
ERLLKAERAA
1960
TGYRDPATGD
1970
TIPLFQAMQK
1980
QLIEKAEALR
1990
LLEVQVATGG
2000
VIDPQHHHRL
2010
PLETAYRRGC
2020
LHKDIYALIS
2030
DQKHMRKRFV
2040
DPNTQEKVSY
2050
RELQERCRPQ
2060
EDTGWLLFPV
2070
NKAARDSEHI
2080
DDETRRALEA
2090
EQVEITVGRF
2100
RGQKPTLWAL
2110
LNSEYVTEEK
2120
KLQLVRMYRT
2130
HTRRALQTVA
2140
QLILELIEKQ
2150
ETSNKHLWFQ
2160
GIRRQITASE
2170
LLSSAIITEE
2180
MLQDLETGRS
2190
TTQELMEDDR
2200
VKRYLEGTSC
2210
IAGVLVPAKD
2220
QPGRQEKMSI
2230
YQAMWKGVLR
2240
PGTALVLLEA
2250
QAATGFVIDP
2260
VRNLRLSVEE
2270
AVAAGVVGGE
2280
IQEKLLSAER
2290
AVTGYTDPYT
2300
GQQISLFQAM
2310
QKDLIVREHG
2320
IRLLEAQIAT
2330
GGVIDPVHSH
2340
RVPVDVAYRR
2350
GYFDEEMNRV
2360
LADPSDDTKG
2370
FFDPNTHENL
2380
TYVQLLRRCV
2390
PDPDTGLYML
2400
QLAGRGSAVH
2410
QLSEELRCAL
2420
RDARVTPGSG
2430
ALQGQSVSVW
2440
ELLFYREVSE
2450
DRRQDLLSRY
2460
RAGTLTVEEL
2470
GATLTSLLAQ
2480
AQAQARAEAE
2490
AGSPRPDPRE
2500
ALRAATMEVK
2510
VGRLRGRAVP
2520
VWDVLASGYV
2530
SRAAREELLA
2540
EFGSGTLDLP
2550
ALTRRLTAII
2560
EEAEEAPGAR
2570
PQLQDAWRGP
2580
REPGPAGRGD
2590
GDSGRSQREG
2600
QGEGETQEAA
2610
AAAAAAAARR
2620
QEQTLRDATM
2630
EVQRGQFQGR
2640
PVSVWDVLFS
2650
SYLSEARRDE
2660
LLAQHAAGAL
2670
GLPDLVAVLT
2680
RVIEETEERL
2690
SKVSFRGLRR
2700
QVSASELHTS
2710
GILGPETLRD
2720
LAQGTKTLQE
2730
VTEMDSVKRY
2740
LEGTSCIAGV
2750
LVPAKDQPGR
2760
QEKMSIYQAM
2770
WKGVLRPGTA
2780
LVLLEAQAAT
2790
GFVIDPVRNL
2800
RLSVEEAVAA
2810
GVVGGEIQEK
2820
LLSAERAVTG
2830
YTDPYTGQQI
2840
SLFQAMQKDL
2850
IVREHGIRLL
2860
EAQIATGGVI
2870
DPVHSHRVPV
2880
DVAYQRGYFD
2890
EEMNRVLADP
2900
SDDTKGFFDP
2910
NTHENLTYVQ
2920
LLRRCVPDPD
2930
TGLYMLQLAG
2940
RGSAVHQLSE
2950
ELRCALRDAR
2960
VTPGSGALQG
2970
QSVSVWELLF
2980
YREVSEDRRQ
2990
DLLSRYRAGT
3000
LTVEELGATL
3010
TSLLAQAQAQ
3020
ARAEAEAGSP
3030
RPDPREALRA
3040
ATMEVKVGRL
3050
RGRAVPVWDV
3060
LASGYVSRAA
3070
REELLAEFGS
3080
GTLDLPALTR
3090
RLTAIIEEAE
3100
EAPGARPQLQ
3110
DAWRGPREPG
3120
PAGRGDGDSG
3130
RSQREGQGEG
3140
ETQEAAAAAR
3150
RQEQTLRDAT
3160
MEVQRGQFQG
3170
RPVSVWDVLF
3180
SSYLSEARRD
3190
ELLAQHAAGA
3200
LGLPDLVAVL
3210
TRVIEETEER
3220
LSKVSFRGLR
3230
CQVSASELHT
3240
SGILGPETLR
3250
DLAQGTKTLQ
3260
EVTEMDSVKR
3270
YLEGTSCIAG
3280
VLVPAKDQPG
3290
RQEKMSIYQA
3300
MWKGVLRPGT
3310
ALVLLEAQAA
3320
TGFVIDPVRN
3330
LRLSVEEAVA
3340
AGVVGGEIQE
3350
KLLSAERAVT
3360
GYTDPYTGQQ
3370
ISLFQAMQKD
3380
LIVREHGIRL
3390
LEAQIATGGV
3400
IDPVHSHRVP
3410
VDVAYRRGYF
3420
DEEMNRVLAD
3430
PSDDTKGFFD
3440
PNTHENLTYV
3450
QLLRRCVPDP
3460
DTGLYMLQLA
3470
GRGSAVHQLS
3480
EELRCALRDA
3490
RVTPGSGALQ
3500
GQSVSVWELL
3510
FYREVSEDRR
3520
QDLLSRYRAG
3530
TLTVEELGAT
3540
LTSLLAQAQA
3550
QARAEAEAGS
3560
PRPDPREALR
3570
AATMEVKVGR
3580
LRGRAVPVWD
3590
VLASGYVSRA
3600
AREELLAEFG
3610
SGTLDLPALT
3620
RRLTAIIEEA
3630
EEAPGARPQL
3640
QDAWRGPREP
3650
GPAGRGDGDS
3660
GRSQREGQGE
3670
GETQEAAAAT
3680
AAARRQEQTL
3690
RDATMEVQRG
3700
QFQGRPVSVW
3710
DVLFSSYLSE
3720
ARRDELLAQH
3730
AAGALGLPDL
3740
VAVLTRVIEE
3750
TEERLSKVSF
3760
RGLRRQVSAS
3770
ELHTSGILGP
3780
ETLRDLAQGT
3790
KTLQEVTEMD
3800
SVKRYLEGTS
3810
CIAGVLVPAK
3820
DQPGRQEKMS
3830
IYQAMWKGVL
3840
RPGTALVLLE
3850
AQAATGFVID
3860
PVRNLRLSVE
3870
EAVAAGVVGG
3880
EIQEKLLSAE
3890
RAVTGYTDPY
3900
TGQQISLFQA
3910
MQKDLIVREH
3920
GIRLLEAQIA
3930
TGGVIDPVHS
3940
HRVPVDVAYR
3950
RGYFDEEMNR
3960
VLADPSDDTK
3970
GFFDPNTHEN
3980
LTYVQLLRRC
3990
VPDPDTGLYM
4000
LQLAGRGSAV
4010
HQLSEELRCA
4020
LRDARVTPGS
4030
GALQGQSVSV
4040
WELLFYREVS
4050
EDRRQDLLSR
4060
YRAGTLTVEE
4070
LGATLTSLLA
4080
QAQAQARAEA
4090
EAGSPRPDPR
4100
EALRAATMEV
4110
KVGRLRGRAV
4120
PVWDVLASGY
4130
VSRAAREELL
4140
AEFGSGTLDL
4150
PALTRRLTAI
4160
IEEAEEAPGA
4170
RPQLQDAWRG
4180
PREPGPAGRG
4190
DGDSGRSQRE
4200
GQGEGETQEA
4210
AAATAAARRQ
4220
EQTLRDATME
4230
VQRGQFQGRP
4240
VSVWDVLFSS
4250
YLSEARRDEL
4260
LAQHAAGALG
4270
LPDLVAVLTR
4280
VIEETEERLS
4290
KVSFRGLRRQ
4300
VSASELHTSG
4310
ILGPETLRDL
4320
AQGTKTLQEV
4330
TEMDSVKRYL
4340
EGTSCIAGVL
4350
VPAKDQPGHQ
4360
EKMSIYQAMW
4370
KGVLRPGTAL
4380
VLLEAQAATG
4390
FVIDPVRNLR
4400
LSVEEAVAAG
4410
VVGGEIQEKL
4420
LSAERAVTGY
4430
TDPYTGQQIS
4440
LFQAMQKDLI
4450
VREHGIRLLE
4460
AQIATGGVID
4470
PVHSHRVPVD
4480
VAYRRGYFDE
4490
EMNRVLAHPS
4500
DDTKGFFDPN
4510
THENLTYVQL
4520
LRRCVPDPDT
4530
GLYMLQLAGR
4540
GSAVHQLSEE
4550
LRCALRDARV
4560
MPGSGALQGQ
4570
SVSVWELLFY
4580
REVSEDRRQD
4590
LLSRYRAGTL
4600
TVEELGATLT
4610
SLLAQAQAQA
4620
RAEAEAEAGS
4630
PRPDPREALR
4640
AATMEVKVGR
4650
LRGRAVPVWD
4660
VLASGYVSGA
4670
AREELLAEFG
4680
SGTLDLPALT
4690
RRLTAIIEEA
4700
EEAPGARPQL
4710
QDAWRGPREP
4720
GPAGRGDGDS
4730
GRSQREGQGE
4740
GETQEAAAAA
4750
RRQEQTLRDA
4760
TMEVQRGQFQ
4770
GRPVSVWDVL
4780
FSSYLSEAHR
4790
DELLAQHAAG
4800
ALGLPDLVAV
4810
LTRVIEETEE
4820
RLSKVSFRGL
4830
RRQVSASELH
4840
TSGILGPETL
4850
RDLAQGTKTL
4860
QEVTEMDSVK
4870
RYLEGTSCIA
4880
GVLVPAKDQP
4890
GRQEKMSIYQ
4900
AMWKGVLRPG
4910
TALVLLEAQA
4920
ATGFVIDPVR
4930
NLRLSVEEAV
4940
AAGVVGGEIQ
4950
EKLLSAERAV
4960
TGYTDPYTGQ
4970
QISLFQAMQK
4980
DLIVREHGIR
4990
LLEAQIATGG
5000
VIDPVHSHRV
5010
PVDVAYRRGY
5020
FDEEMNRVLA
5030
DPSDDTKGFF
5040
DPNTHENLTY
5050
LQLLQRATLD
5060
PETGLLFLSL
SLQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016327 |
apicolateral plasma membrane |
| Cellular Component |
GO:0016323 |
basolateral plasma membrane |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0030056 |
hemidesmosome |
| Cellular Component |
GO:0045111 |
intermediate filament cytoskeleton |
| Molecular Function |
GO:0019215 |
intermediate filament binding |
| Biological Process |
GO:0045109 |
intermediate filament organization |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0050680 |
negative regulation of epithelial cell proliferation |
| Biological Process |
GO:0061045 |
negative regulation of wound healing |
| Biological Process |
GO:0042060 |
wound healing |
Reference
PMID: N/A