Overview
| Uniprot ID | A0A096MJN4 |
|---|
| Protein Name | Septin-4 |
|---|
| Gene Name | Septin4 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 155 |
TDLYRDRKLLGAEER |
| 179 |
HAVDIEEKGVRLRLT |
Function
Filament-forming cytoskeletal GTPase. Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity)
Protein Sequence
10
MIKHFLEDNS
20
DDAELSKFVK
30
DFPGSEPCHP
40
TESKTRVARP
50
QILEPRPQSP
60
DLCDDDVEFR
70
ATLWSQPSDS
80
QQYFCPPAPL
90
SPSSRPRSPW
100
GKLDPYDSSE
110
DDKEYVGFAT
120
LPNQVHRKSV
130
KKGFDFTLMV
140
AGESGLGKST
150
LVNSLFLTDL
160
YRDRKLLGAE
170
ERIMQTVEIT
180
KHAVDIEEKG
190
VRLRLTIVDT
200
PGFGDAVNNT
210
ECWRPVAEYI
220
DQQFEQYFRD
230
ESGLNRKNIQ
240
DNRVHCCLYF
250
ISPFGHGLRP
260
LDVEFMKALH
270
QRVNIVPILA
280
KADTLTPSEV
290
DRKKCKIREE
300
IEHFGIKIYQ
310
FPDCDSDEDE
320
DFKLQDQALK
330
ESIPFAVIGS
340
NTVVEARGRR
350
VRGRLYPWGI
360
VEVENPGHCD
370
FVKLRTMLVR
380
THMQDLKDVT
390
RETHYENYRA
400
QCIQSMTRLV
410
VKERNRNKLT
420
RESGTDFPIP
430
AVPPGTDPET
440
EKLIREKDEE
450
LRRMQEMLHK
IQRQMKETH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0043679 |
axon terminus |
| Cellular Component |
GO:0032153 |
cell division site |
| Cellular Component |
GO:0042995 |
cell projection |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0098691 |
dopaminergic synapse |
| Cellular Component |
GO:0015630 |
microtubule cytoskeleton |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0031514 |
motile cilium |
| Cellular Component |
GO:0043204 |
perikaryon |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0031105 |
septin complex |
| Cellular Component |
GO:0005940 |
septin ring |
| Cellular Component |
GO:0097227 |
sperm annulus |
| Cellular Component |
GO:0036126 |
sperm flagellum |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Biological Process |
GO:0007420 |
brain development |
| Biological Process |
GO:0061640 |
cytoskeleton-dependent cytokinesis |
| Biological Process |
GO:0030317 |
flagellated sperm motility |
| Biological Process |
GO:0061484 |
hematopoietic stem cell homeostasis |
| Biological Process |
GO:0008104 |
intracellular protein localization |
| Biological Process |
GO:2000647 |
negative regulation of stem cell proliferation |
| Biological Process |
GO:0001764 |
neuron migration |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process |
GO:0031398 |
positive regulation of protein ubiquitination |
| Biological Process |
GO:0017157 |
regulation of exocytosis |
| Biological Process |
GO:0048240 |
sperm capacitation |
| Biological Process |
GO:0030382 |
sperm mitochondrion organization |
| Biological Process |
GO:0007286 |
spermatid development |
| Biological Process |
GO:0048515 |
spermatid differentiation |
| Biological Process |
GO:0048729 |
tissue morphogenesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.