Overview
| Uniprot ID | A0A096MK68 |
|---|
| Protein Name | ATP synthase subunit b |
|---|
| Gene Name | Atp5pb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 133 |
IDKLNEEKIAQLEEI |
| 141 |
IAQLEEIKQSSMKQI |
| 146 |
EIKQSSMKQIQDAIN |
| 156 |
QDAINREKAQQALVQ |
| 164 |
AQQALVQKRHYLFDV |
| 212 |
VQDMMRRKEGEHMIN |
| 235 |
SISAQQEKETIAKCI |
| 240 |
QEKETIAKCIGDLKM |
Function
Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements
Protein Sequence
10
GHRDIGTAVW
20
IFADNAVPGG
30
TFCRRHSGVL
40
QATRVFHTGQ
50
PRLAPLPPLP
60
EYGGKVRLGL
70
IPEEFFQFLY
80
PKTGVTGPYV
90
LGTGLSLYFL
100
SKEIYVITPE
110
TFSTISVVGL
120
IVYVIKKYGA
130
SIGEFIDKLN
140
EEKIAQLEEI
150
KQSSMKQIQD
160
AINREKAQQA
170
LVQKRHYLFD
180
VQRNNIALAL
190
EVTYRERLHK
200
AYKEVKNRLD
210
YHISVQDMMR
220
RKEGEHMINW
230
VEKHVIQSIS
240
AQQEKETIAK
250
CIGDLKMLAK
KAQAQPIM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0015078 |
proton transmembrane transporter activity |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.