Search Results

Overview

Uniprot IDA0A096P6L8
Protein NameFibronectin
Gene NameFn1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
101 PEETCFDKYTGNTYK
1039 LTRGGQPKQYNVGPM
1049 NVGPMASKYPLRNLQ
1076 KGNQQSPKATGVFTT
1115 PAPRIGFKLGVRPSQ
1726 VTNIDRPKGLAFTDV
181 GKGEWTCKPIAEKCF
1851 VRVTPKEKTGPMKEI
1886 EVSVYALKDTLTSRP
2026 RITGYIIKYEKPGSP
2029 GYIIKYEKPGSPPRE
249 RIGDTWSKKDNRGNL
554 GQGRGRWKCDPIDQC
91 RGFNCESKPEPEETC
986 VHQGRESKPLTAQQT

Function

Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling

Protein Sequence

10 MLRGPGPGRL 20 LLLAVLCLGT 30 SVRCTETGKS 40 KRQAQQIVQP 50 PSPVAVSQSK 60 PGCFDNGKHY 70 QINQQWERTY 80 LGNALVCTCY 90 GGSRGFNCES 100 KPEPEETCFD 110 KYTGNTYKVG 120 DTYERPKDSM 130 IWDCTCIGAG 140 RGRISCTIAN 150 RCHEGGQSYK 160 IGDKWRRPHE 170 TGGYMLECLC 180 LGNGKGEWTC 190 KPIAEKCFDH 200 AAGTSYVVGE 210 TWEKPYQGWM 220 MVDCTCLGEG 230 NGRITCTSRN 240 RCNDQDTRTS 250 YRIGDTWSKK 260 DNRGNLLQCV 270 CTGNGRGEWK 280 CERHVLQSAS 290 AGSGSFTDVR 300 TAIYQPQTHP 310 QPAPYGHCVT 320 DSGVVYSVGM 330 QWLKSQGDKQ 340 MLCTCLGNGV 350 SCQETAVTQT 360 YGGNSNGEPC 370 VLPFTYNGRT 380 FYSCTTEGRQ 390 DGHLWCSTTS 400 NYEQDQKYSF 410 CTDHAVLVQT 420 RGGNSNGALC 430 HFPFLYNNRN 440 YTDCTSEGRR 450 DNMKWCGTTQ 460 NYDADQKFGF 470 CPMAAHEEIC 480 TTNEGVMYRI 490 GDQWDKQHDL 500 GHMMRCTCVG 510 NGRGEWACIP 520 YSQLRDQCIV 530 DDITYNVNDT 540 FHKRHEEGHM 550 LNCTCFGQGR 560 GRWKCDPIDQ 570 CQDSETRTFY 580 QIGDSWEKFV 590 HGVRYQCYCY 600 GRGIGEWHCQ 610 PLQTYPGTTG 620 PVQVIITETP 630 SQPNSHPIQW 640 NAPEPSHITK 650 YILRWRPKTS 660 TGRWKEATIP 670 GHLNSYTIKG 680 LTPGVIYEGQ 690 LISIQQYGHQ 700 EVTRFDFTTS 710 ASTPVTSNTV 720 TGETAPFSPV 730 VATSESVTEI 740 TASSFVVSWV 750 SASDTVSGFR 760 VEYELSEEGD 770 EPQYLDLPST 780 ATSVNIPDLL 790 PGRKYIVNVY 800 QISEEGKQSL 810 ILSTSQTTAP 820 DAPPDPTVDQ 830 VDDTSIVVRW 840 SRPQAPITGY 850 RIVYSPSVEG 860 SSTELNLPET 870 ANSVTLSDLQ 880 PGVQYNITIY 890 AVEENQESTP 900 VFIQQETTGV 910 PRSDDVPAPK 920 DLQFVEVTDV 930 KVTIMWTPPN 940 SAVTGYRVDV 950 LPVNLPGEHG 960 QRLPVNRNTF 970 AEVTGLSPGV 980 TYLFKVFAVH 990 QGRESKPLTA 1000 QQTTKLDAPT 1010 NLQFVNETDR 1020 TVLVTWTPPR 1030 ARIAGYRLTV 1040 GLTRGGQPKQ 1050 YNVGPMASKY 1060 PLRNLQPGSE 1070 YTVTLMAVKG 1080 NQQSPKATGV 1090 FTTLQPLRSI 1100 PPYNTEVTET 1110 TIVITWTPAP 1120 RIGFKLGVRP 1130 SQGGEAPREV 1140 TSDSGSIVVS 1150 GLTPGVEYTY 1160 TIQVLRDGQE 1170 RDAPIVNRVV 1180 TPLSPPTNLH 1190 LEANPDTGVL 1200 TVSWERSTTP 1210 DITGYRITTT 1220 PTNGQQGTAL 1230 EEVVHADQSS 1240 CTFENLNPGL 1250 EYNVSVYTVK 1260 DDKESAPISD 1270 TVIPEVPQLT 1280 DLSFVDITDS 1290 SIGLRWTPLN 1300 SSTIIGYRIT 1310 VVAAGEGIPI 1320 FEDFVDSSVG 1330 YYTVTGLEPG 1340 IDYDISVITL 1350 INGGESAPTT 1360 LTQQTAVPPP 1370 TDLRFTNIGP 1380 DTMRVTWAPP 1390 PSIELTNLLV 1400 RYSPVKNEED 1410 VAELSISPSD 1420 NAVVLTNLLP 1430 GTEYLVSVSS 1440 VYEQHESIPL 1450 RGRQKTGLDS 1460 PTGFDSSDVT 1470 ANSFTVHWVA 1480 PRAPITGYII 1490 RHHAEHSAGR 1500 PRQDRVPPSR 1510 NSITLTNLNP 1520 GTEYIVTIIA 1530 VNGREESPPL 1540 IGQQSTVSDV 1550 PRDLEVIAST 1560 PTSLLISWEP 1570 PAVSVRYYRI 1580 TYGETGGNSP 1590 VQEFTVPGSK 1600 STATINNIKP 1610 GADYTITLYA 1620 VTGRGDSPAS 1630 SKPVSINYQT 1640 EIDKPSQMQV 1650 TDVQDNSISV 1660 RWLPSTSPVT 1670 GYRVTTAPKN 1680 GLGPTKSQTV 1690 SPDQTEMTIE 1700 GLQPTVEYVV 1710 SVYAQNRNGE 1720 SQPLVQTAVT 1730 NIDRPKGLAF 1740 TDVDVDSIKI 1750 AWESPQGQVS 1760 RYRVTYSSPE 1770 DGIHELFPAP 1780 DGDEDTAELH 1790 GLRPGSEYTV 1800 SVVALHGGME 1810 SQPLIGVQST 1820 AIPAPTNLKF 1830 TQVSPTTLTA 1840 QWTAPSVKLT 1850 GYRVRVTPKE 1860 KTGPMKEINL 1870 SPDSTSVIVS 1880 GLMVATKYEV 1890 SVYALKDTLT 1900 SRPAQGVVTT 1910 LENVSPPRRA 1920 RVTDATETTI 1930 TISWRTKTET 1940 ITGFQVDAIP 1950 ANGQTPVQRT 1960 ISPDVRSYTI 1970 TGLQPGTDYK 1980 IHLYTLNDNA 1990 RSSPVVIDAS 2000 TAIDAPSNLR 2010 FLTTTPNSLL 2020 VSWQAPRARI 2030 TGYIIKYEKP 2040 GSPPREVVPR 2050 PRPGVTEATI 2060 TGLEPGTEYT 2070 IYVIALKNNQ 2080 KSEPLIGRKK 2090 TDELPQLVTL 2100 PHPNLHGPEI 2110 LDVPSTVQKT 2120 PFVTNPGYDT 2130 ENGIQLPGTS 2140 HQQPSVGQQM 2150 IFEEHGFRRT 2160 TPPTAATPVR 2170 LRPRPYLPNV 2180 DEEVQIGHVP 2190 RGDVDYHLYP 2200 HVPGLNPNAS 2210 TGQEALSQTT 2220 ISWTPFQESS 2230 EYIISCQPVG 2240 TDEEPLQFQV 2250 PGTSTSATLT 2260 GLTRGVTYNI 2270 IVEALHNQRR 2280 HKVREEVVTV 2290 GNTVNEGLNQ 2300 PTDDSCFDPY 2310 TVSHYAVGEE 2320 WERLSDSGFK 2330 LTCQCLGFGS 2340 GHFRCDSSKW 2350 CHDNGVNYKI 2360 GEKWDRQGEN 2370 GQRMSCTCLG 2380 NGKGEFKCDP 2390 HEATCYDDGK 2400 TYHVGEQWQK 2410 EYLGAICSCT 2420 CFGGQRGWRC 2430 DNCRRPGAAE 2440 PSPDGTTGHT 2450 YNQYTQRYHQ 2460 RTNTNVNCPI 2470 ECFMPLDVQA DRDDSRE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005604 basement membrane
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005577 fibrinogen complex
Molecular Function GO:0008201 heparin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0016504 peptidase activator activity
Molecular Function GO:0002020 protease binding
Molecular Function GO:0043394 proteoglycan binding
Molecular Function GO:0048018 receptor ligand activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0001525 angiogenesis
Biological Process GO:0051702 biological process involved in interaction with symbiont
Biological Process GO:0072378 blood coagulation, fibrin clot formation
Biological Process GO:0007160 cell-matrix adhesion
Biological Process GO:0035987 endodermal cell differentiation
Biological Process GO:0043542 endothelial cell migration
Biological Process GO:0048484 enteric nervous system development
Biological Process GO:0033622 integrin activation
Biological Process GO:0007229 integrin-mediated signaling pathway
Biological Process GO:0150102 negative regulation of monocyte activation
Biological Process GO:0071635 negative regulation of transforming growth factor beta production
Biological Process GO:1901166 neural crest cell migration involved in autonomic nervous system development
Biological Process GO:0048146 positive regulation of fibroblast proliferation
Biological Process GO:0010628 positive regulation of gene expression
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0070372 regulation of ERK1 and ERK2 cascade
Biological Process GO:0014850 response to muscle activity
Biological Process GO:0034446 substrate adhesion-dependent cell spreading

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.