Search Results
Overview
| Uniprot ID | A0A0A0MXY4 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase |
| Gene Name | Trip12 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1034 | GRLSDVLKRKRLPKR |
| 259 | SKTGGSSKFDWAARF |
| 276 | KVSLPKTKLSLPGSS |
| 298 | GPSGLQAKLASLRKS |
Function
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins
Protein Sequence
10
MSNRPNNNPG
20
GSLRRSQRNT
30
AGAQPQDDSI
40
GGRSCSSSSA
50
VIVPQPEDPD
60
RANTSERQKT
70
GQVPKKDNSR
80
GVKRSASPDY
90
NRTNSPSSAK
100
KPRAFQHIES
110
LSETNKPPSK
120
SKKRHLDQEQ
130
QLKSAQLPST
140
SKAHTRKSVA
150
AGSSRSQKRK
160
RTESSCVKSG
170
SGSESTGAEE
180
RSAKPTKLAS
190
KSATSAKAGC
200
STITDSSSAA
210
STSSSSSAVA
220
SASSTVPAGA
230
RVKQGKDQNK
240
ARRSRSASSP
250
SPRRSSREKE
260
QSKTGGSSKF
270
DWAARFSPKV
280
SLPKTKLSLP
290
GSSKSETSKP
300
GPSGLQAKLA
310
SLRKSTKKRS
320
ESPPAELPSL
330
RRSTRQKTTG
340
SCASTSRRGS
350
GLGKRGAAEA
360
RRQEKMADPE
370
GNQETVNSSA
380
ARTDEAPQGA
390
AASSSVAGAV
400
GMTTSGESES
410
DDSEMGRLQA
420
LLEARGLPPH
430
LFGPLGPRMS
440
QLFHRTIGSG
450
ASSKAQQLLQ
460
GLQASDESQQ
470
LQAVIEMCQL
480
LVMGNEETLG
490
GFPVKSVVPA
500
LITLLQMEHN
510
FDIMNHACRA
520
LTYMMEALPR
530
SSAVVVDAIP
540
VFLEKLQVIQ
550
CIDVAEQALT
560
ALEMLSRRHS
570
KAILQAGGLA
580
DCLLYLEFFS
590
INAQRNALAI
600
AANCCQSITP
610
DEFHFVADSL
620
PLLTQRLTHQ
630
DKKSVESTCL
640
CFARLVDNFQ
650
HEENLLQQVA
660
SKDLLTNVQQ
670
LLVVTPPILS
680
SGMFIMVVRM
690
FSLMCSNCPT
700
LAVQLMKQNI
710
AETLHFLLCG
720
ASNGSCQEQI
730
DLVPRSPQEL
740
YELTSLICEL
750
MPCLPKEGIF
760
AVDTMLKKGN
770
AQNTDGAIWQ
780
WRDDRGLWHP
790
YNRIDSRIIE
800
AAHQVGEDEI
810
SLSTLGRVYT
820
IDFNSMQQIN
830
EDTGTARAIQ
840
RKPNPLANTN
850
TSGYSDLKKD
860
DARAQLMKED
870
PELAKSFIKT
880
LFGVLYEVYS
890
SSAGPAVRHK
900
CLRAILRIIY
910
FADAELLKDV
920
LKNHAVSSHI
930
ASMLSSQDLK
940
IVVGALQMAE
950
ILMQKLPDIF
960
SVYFRREGVM
970
HQVKHLAESE
980
SLLTSPPKAC
990
TNGSGSLGST
1000
TPASSGTATA
1010
ATNASADLGS
1020
PSLQHSRDDS
1030
LDLSPQGRLS
1040
DVLKRKRLPK
1050
RGPRRPKYSP
1060
PRDDDKVDNQ
1070
AKSPTTTQSP
1080
KSSFLASLNP
1090
KTWGRLSAQS
1100
NSNNIEPART
1110
AGVSGLARAA
1120
SKDTISNNRE
1130
KIKGWIKEQA
1140
HKFVERYFSS
1150
ENMDGSNPAL
1160
NVLQRLCAAT
1170
EQLNLQVDGG
1180
AECLVEIRSI
1190
VSESDVSSFE
1200
IQHSGFVKQL
1210
LLYLTSKSEK
1220
DAVSREIRLK
1230
RFLHVFFSSP
1240
LPGEEPVGRV
1250
EPVGHAPLLA
1260
LVHKMNNCLS
1270
QMEQFPVKVH
1280
DFPSGNGSGG
1290
SFSLNRGSQA
1300
LKFFNTHQLK
1310
CQLQRHPDCA
1320
NVKQWKGGPV
1330
KIDPLALVQA
1340
IERYLVVRGI
1350
FRILHSVFML
1360
SYPLRYKPVR
1370
EDEESSKDCV
1380
GGKRGRAQTA
1390
PTKTSPRNAK
1400
KHDELWHDGV
1410
CPSVANPLEV
1420
YLIPTPPENI
1430
TFEDPSLDVI
1440
LLLRVLHAIS
1450
RYWYYLYDNA
1460
MCKEIIPTSE
1470
FINSKLTAKA
1480
NRQLQDPLVI
1490
MTGNIPTWLT
1500
ELGKTCPFFF
1510
PFDTRQMLFY
1520
VTAFDRDRAM
1530
QRLLDTNPEI
1540
NQSDSQDSRV
1550
APRLDRKKRT
1560
VNREELLKQA
1570
ESVMQDLGSS
1580
RAMLEIQYEN
1590
EVGTGLGPTL
1600
EFYALVSQEL
1610
QRADLGLWRG
1620
EEVTLSNPKG
1630
SQEGTKYIQN
1640
LQGLFALPFG
1650
RTAKPAHIAK
1660
VKMKFRFLGK
1670
LMAKAIMDFR
1680
LVDLPLGLPF
1690
YKWMLRQETS
1700
LTSHDLFDID
1710
PVVARSVYHL
1720
EDIVRQKKRL
1730
EQDKSQTKES
1740
LQYALETLTM
1750
NGCSVEDLGL
1760
DFTLPGFPNI
1770
ELKKGGKDIP
1780
VTIHNLEEYL
1790
RLVIFWALNE
1800
GVCRQFDSFR
1810
DGFESVFPLS
1820
HLQYFYPEEL
1830
DQLLCGSKAD
1840
TWDAKTLMEC
1850
CRPDHGYTHD
1860
SRAVKFLFEI
1870
LSSFDNEQQR
1880
LFLQFVTGSP
1890
RLPVGGFRSL
1900
NPPLTIVRKT
1910
FESTENPDDF
1920
LPSVMTCVNY
1930
LKLPDYSSIE
1940
IMRDKLLIAA
1950
REGQQSFHLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.