Search Results

Overview

Uniprot IDA0A0A0MXY4
Protein NameE3 ubiquitin-protein ligase
Gene NameTrip12
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1034 GRLSDVLKRKRLPKR
259 SKTGGSSKFDWAARF
276 KVSLPKTKLSLPGSS
298 GPSGLQAKLASLRKS

Function

E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins

Protein Sequence

10 MSNRPNNNPG 20 GSLRRSQRNT 30 AGAQPQDDSI 40 GGRSCSSSSA 50 VIVPQPEDPD 60 RANTSERQKT 70 GQVPKKDNSR 80 GVKRSASPDY 90 NRTNSPSSAK 100 KPRAFQHIES 110 LSETNKPPSK 120 SKKRHLDQEQ 130 QLKSAQLPST 140 SKAHTRKSVA 150 AGSSRSQKRK 160 RTESSCVKSG 170 SGSESTGAEE 180 RSAKPTKLAS 190 KSATSAKAGC 200 STITDSSSAA 210 STSSSSSAVA 220 SASSTVPAGA 230 RVKQGKDQNK 240 ARRSRSASSP 250 SPRRSSREKE 260 QSKTGGSSKF 270 DWAARFSPKV 280 SLPKTKLSLP 290 GSSKSETSKP 300 GPSGLQAKLA 310 SLRKSTKKRS 320 ESPPAELPSL 330 RRSTRQKTTG 340 SCASTSRRGS 350 GLGKRGAAEA 360 RRQEKMADPE 370 GNQETVNSSA 380 ARTDEAPQGA 390 AASSSVAGAV 400 GMTTSGESES 410 DDSEMGRLQA 420 LLEARGLPPH 430 LFGPLGPRMS 440 QLFHRTIGSG 450 ASSKAQQLLQ 460 GLQASDESQQ 470 LQAVIEMCQL 480 LVMGNEETLG 490 GFPVKSVVPA 500 LITLLQMEHN 510 FDIMNHACRA 520 LTYMMEALPR 530 SSAVVVDAIP 540 VFLEKLQVIQ 550 CIDVAEQALT 560 ALEMLSRRHS 570 KAILQAGGLA 580 DCLLYLEFFS 590 INAQRNALAI 600 AANCCQSITP 610 DEFHFVADSL 620 PLLTQRLTHQ 630 DKKSVESTCL 640 CFARLVDNFQ 650 HEENLLQQVA 660 SKDLLTNVQQ 670 LLVVTPPILS 680 SGMFIMVVRM 690 FSLMCSNCPT 700 LAVQLMKQNI 710 AETLHFLLCG 720 ASNGSCQEQI 730 DLVPRSPQEL 740 YELTSLICEL 750 MPCLPKEGIF 760 AVDTMLKKGN 770 AQNTDGAIWQ 780 WRDDRGLWHP 790 YNRIDSRIIE 800 AAHQVGEDEI 810 SLSTLGRVYT 820 IDFNSMQQIN 830 EDTGTARAIQ 840 RKPNPLANTN 850 TSGYSDLKKD 860 DARAQLMKED 870 PELAKSFIKT 880 LFGVLYEVYS 890 SSAGPAVRHK 900 CLRAILRIIY 910 FADAELLKDV 920 LKNHAVSSHI 930 ASMLSSQDLK 940 IVVGALQMAE 950 ILMQKLPDIF 960 SVYFRREGVM 970 HQVKHLAESE 980 SLLTSPPKAC 990 TNGSGSLGST 1000 TPASSGTATA 1010 ATNASADLGS 1020 PSLQHSRDDS 1030 LDLSPQGRLS 1040 DVLKRKRLPK 1050 RGPRRPKYSP 1060 PRDDDKVDNQ 1070 AKSPTTTQSP 1080 KSSFLASLNP 1090 KTWGRLSAQS 1100 NSNNIEPART 1110 AGVSGLARAA 1120 SKDTISNNRE 1130 KIKGWIKEQA 1140 HKFVERYFSS 1150 ENMDGSNPAL 1160 NVLQRLCAAT 1170 EQLNLQVDGG 1180 AECLVEIRSI 1190 VSESDVSSFE 1200 IQHSGFVKQL 1210 LLYLTSKSEK 1220 DAVSREIRLK 1230 RFLHVFFSSP 1240 LPGEEPVGRV 1250 EPVGHAPLLA 1260 LVHKMNNCLS 1270 QMEQFPVKVH 1280 DFPSGNGSGG 1290 SFSLNRGSQA 1300 LKFFNTHQLK 1310 CQLQRHPDCA 1320 NVKQWKGGPV 1330 KIDPLALVQA 1340 IERYLVVRGI 1350 FRILHSVFML 1360 SYPLRYKPVR 1370 EDEESSKDCV 1380 GGKRGRAQTA 1390 PTKTSPRNAK 1400 KHDELWHDGV 1410 CPSVANPLEV 1420 YLIPTPPENI 1430 TFEDPSLDVI 1440 LLLRVLHAIS 1450 RYWYYLYDNA 1460 MCKEIIPTSE 1470 FINSKLTAKA 1480 NRQLQDPLVI 1490 MTGNIPTWLT 1500 ELGKTCPFFF 1510 PFDTRQMLFY 1520 VTAFDRDRAM 1530 QRLLDTNPEI 1540 NQSDSQDSRV 1550 APRLDRKKRT 1560 VNREELLKQA 1570 ESVMQDLGSS 1580 RAMLEIQYEN 1590 EVGTGLGPTL 1600 EFYALVSQEL 1610 QRADLGLWRG 1620 EEVTLSNPKG 1630 SQEGTKYIQN 1640 LQGLFALPFG 1650 RTAKPAHIAK 1660 VKMKFRFLGK 1670 LMAKAIMDFR 1680 LVDLPLGLPF 1690 YKWMLRQETS 1700 LTSHDLFDID 1710 PVVARSVYHL 1720 EDIVRQKKRL 1730 EQDKSQTKES 1740 LQYALETLTM 1750 NGCSVEDLGL 1760 DFTLPGFPNI 1770 ELKKGGKDIP 1780 VTIHNLEEYL 1790 RLVIFWALNE 1800 GVCRQFDSFR 1810 DGFESVFPLS 1820 HLQYFYPEEL 1830 DQLLCGSKAD 1840 TWDAKTLMEC 1850 CRPDHGYTHD 1860 SRAVKFLFEI 1870 LSSFDNEQQR 1880 LFLQFVTGSP 1890 RLPVGGFRSL 1900 NPPLTIVRKT 1910 FESTENPDDF 1920 LPSVMTCVNY 1930 LKLPDYSSIE 1940 IMRDKLLIAA 1950 REGQQSFHLS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.