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Overview

Uniprot ID	A0A0A0MXY5
Protein Name	ATP-dependent 6-phosphofructokinase
Gene Name	Pfkp
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
649	FDRNFGTKISAKAME

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 GMNAAVRAVV 20 RMGIYTGAKV 30 YFIYEGYQGM 40 VDGGSNIVEA 50 KWECVSSILQ 60 VGGTIIGSAR 70 CQAFRSREGR 80 LKAACNLVRL 90 GITNLCVIGG 100 DGSLTGANLF 110 RKEWSGLLEE 120 LAKNGEIDSD 130 TVKKHAYLNV 140 VGMVGIDNDF 150 CGTDMTIGTD 160 SALHRIIEVV 170 DAIMTTAQSH 180 QRTFVLEVMG 190 RHCGYLALVS 200 ALACGADWVF 210 LPESPPEEGW 220 EEEMCLKLSE 230 NRARKKRLNI 240 IIVSEGAIDT 250 QNKPITSEKI 260 KELVVTNLGF 270 DTRVTILGHV 280 QRGGTPSAFD 290 RILASRMGVE 300 AVLALLEATP 310 ETPACVVSLR 320 GNQAVRLPLM 330 ECVQMTQDVQ 340 KAMDERRFDE 350 AVKLRGRSFE 360 GNLNTYKRLA 370 IKEPDDKIPK 380 SNCNVAIINV 390 GAPAAGMNAA 400 VRSAVRVGIA 410 EGHKMFAIYD 420 GFDGLANGQX 430 XEIGWGDVGG 440 WTGQGGSILG 450 TKRTLPGKYL 460 EKIAEQMHSK 470 NINALLIIGG 480 FEAYLGLLEL 490 AAARNKHEAF 500 CVPMVMVPAT 510 VSNNVPGSDF 520 SIGADTALNT 530 ITDTCDRIKQ 540 SASGTKRRVF 550 IIETMGGYCG 560 YLANMGGLAA 570 GADAAYIFEE 580 QFDIRDLQSN 590 VMHLTEKMKT 600 ARRGLVLRNE 610 NCSVNYTTDF 620 IYQLYSEEGK 630 GVFDCRKNVL 640 GHMQQGGAPS 650 PFDRNFGTKI 660 SAKAMEWISA 670 KLKGSHGTGK 680 KFVSDDSICV 690 LGIQKRDLLF 700 KPVAELRKAT 710 DFEHRIPKQQ 720 WWLKLRPIMK 730 ILAKYEASYD 740 MSDVGKLEPV HNHGELSAI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0003872	6-phosphofructokinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0070095	fructose-6-phosphate binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process
Biological Process	GO:0006002	fructose 6-phosphate metabolic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.