Overview
| Uniprot ID | A0A0A0MY00 |
|---|
| Protein Name | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
|---|
| Gene Name | Acadsb |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 278 |
PETSVLGKIGHGYKY |
Function
Short and branched chain specific acyl-CoA dehydrogenase that catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, acts specifically on short and branched chain acyl-CoA derivatives such as (S)-2-methylbutyryl-CoA as well as short straight chain acyl-CoAs such as butyryl-CoA (butanoyl-CoA). Plays an important role in the metabolism of L-isoleucine by catalyzing the dehydrogenation of 2-methylbutyryl-CoA, one of the steps of the L-isoleucine catabolic pathway. Can also act on valproyl-CoA, a metabolite of valproic acid, an antiepileptic drug
Protein Sequence
10
MAVSAFQLWR
20
AGGLLRRNFL
30
THSSSWKIPP
40
RVLKSSQPEA
50
LLSVTNNALC
60
FAPLQTFTDE
70
DIMMQKAVKK
80
FAQEQIAPLV
90
STMDENSKME
100
KSVIQGLFQQ
110
GMMGIEVEAK
120
YGGTEASFLC
130
SVLVIEELAK
140
VDASVALLCD
150
IQNTVINKLF
160
RKHGTEEQKA
170
TYLPKLVTEK
180
LGSFCLSEAG
190
AGSDSFALKT
200
RADKSGNYYV
210
INGSKMWISN
220
AEHAELFLVF
230
ANVDPPSGYR
240
GITCFLVDRD
250
TEGFQIGRRE
260
NKMGIRASST
270
CQLTFENVKV
280
PETSVLGKIG
290
HGYKYAIGSL
300
NEGRIGIAAQ
310
MLGLAQGCFD
320
YTIPYIKERM
330
QFGKRIFDFQ
340
GLQHQVAHVA
350
TQLEAARLLT
360
YNAARLVEAG
370
RPFIKEASMA
380
KYYASEVAGL
390
TTSKCIEWMG
400
GVGYTKDYPV
410
EKFFRDAKIG
420
TIYEGTSNIQ
430
LNTIAKHIDA
440
DFRVYKSLTM
450
PAFGKKKPFE
460
EVLASLTGTG
NCLKKYWHH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Molecular Function |
GO:0050660 |
flavin adenine dinucleotide binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003853 |
short-chain 2-methyl fatty acyl-CoA dehydrogenase activity |
| Biological Process |
GO:0006635 |
fatty acid beta-oxidation |
| Biological Process |
GO:0006550 |
L-isoleucine catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.