Search Results
Overview
| Uniprot ID | A0A0A0MY07 |
|---|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase |
| Gene Name | Usp15 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | IFNIPDEKEARLWNK |
Function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes
Protein Sequence
10
MAEGGAADLD
20
TQRSDIATLL
30
KTSLRKGDTW
40
YLVDSRWFKQ
50
WKKYVGFDSW
60
DKYQMGDQNV
70
YPGPIDNSGL
80
LKDGDAQSLK
90
EHLIDELDYI
100
LLPTEGWNKL
110
VSWYTLMEGQ
120
EPIARKVVEQ
130
GMFVKHCKVE
140
VYLTELKLCE
150
NGNMNNVVTR
160
RFSKADTIDT
170
IEKEIRKIFN
180
IPDEKEARLW
190
NKYMSNTFEP
200
LNKPDSTIQD
210
AGLYQGQVLV
220
IEQKNEDGTW
230
PRGPSAPKSP
240
GASNFSTLPK
250
ISPSSLSNNY
260
NNINNRNVKN
270
SNYCLPSYTA
280
YKNYDYSEPG
290
RNNEQPGLCG
300
LSNLGNTCFM
310
NSAIQCLSNT
320
PPLTEYFLND
330
KYQEELNFDN
340
PLGMRGEIAK
350
SYAELIKQMW
360
SGKFSYVTPR
370
AFKTQVGRFA
380
PQFSGYQQQD
390
CQELLAFLLD
400
GLHEDLNRIR
410
KKPYIQLKDA
420
DGRPDKVVAE
430
EAWENHLKRN
440
DSIIVDIFHG
450
LFKSTLVCPE
460
CAKISVTFDP
470
FCYLTLPLPM
480
KKERSLEVYL
490
VRMDPLAKPM
500
QYKVIVPKIG
510
NILDLCTALS
520
ALSGVPADKM
530
IVTDIYNHRF
540
HRIFAMDENL
550
SSIMERDDIY
560
VFEININRTE
570
DTEHVVIPVC
580
LREKFRHSSY
590
THHTGSSLFG
600
QPFLMAVPRN
610
NTEDKLYNLL
620
LLRMCRYVKM
630
STETEETDGP
640
LRCCEDQNIN
650
GNGPNGIHEE
660
GSPSEMETDE
670
PDDESSQDQE
680
LPSENENSQS
690
EDSVGGDNDS
700
ENGLCTEETC
710
KGQLTGHKKR
720
LFTFQFNNLG
730
NTDINYIKDD
740
TRHIRFDDRQ
750
LRLDERSFLA
760
LDWDPDLKKR
770
YFDENAAEDF
780
EKHESVEYKP
790
PKRPFVKLKD
800
CIELFTTKEK
810
LGAEDPWYCP
820
NCKEHQQATK
830
KLDLWSLPPV
840
LVVHLKRFSY
850
SRYMRDKLDT
860
LVDFPISDLD
870
MSEFLINPNA
880
GPCRYNLIAV
890
SNHYGGMGGG
900
HYTAFAKNKD
910
DGKWYYFDDS
920
SVSTASEDQI
930
VSKAAYVLFY
940
QRQDTFSGTG
950
FFPLDRETKG
960
ASAATGVPLE
970
SDEDSNDNDN
980
DLENENCMHT
N
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006508 | proteolysis |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016604 | nuclear body |
| Molecular Function | GO:0004843 | cysteine-type deubiquitinase activity |
| Molecular Function | GO:0004197 | cysteine-type endopeptidase activity |
| Molecular Function | GO:1990380 | K48-linked deubiquitinase activity |
| Molecular Function | GO:0046332 | SMAD binding |
| Molecular Function | GO:0005160 | transforming growth factor beta receptor binding |
| Molecular Function | GO:0061649 | ubiquitin-modified histone reader activity |
| Biological Process | GO:0030509 | BMP signaling pathway |
| Biological Process | GO:0035520 | monoubiquitinated protein deubiquitination |
| Biological Process | GO:1905035 | negative regulation of antifungal innate immune response |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:1900246 | positive regulation of RIG-I signaling pathway |
| Biological Process | GO:1990167 | protein K27-linked deubiquitination |
| Biological Process | GO:0051252 | regulation of RNA metabolic process |
| Biological Process | GO:0140673 | transcription elongation-coupled chromatin remodeling |
| Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.