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Overview

Uniprot IDA0A0C4DG33
Protein NamePeroxisomal ATPase PEX1
Gene NamePEX1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
876 FIRAQAAKPCILFFD

Function

Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5

Protein Sequence

10 MWGSDRLAGA 20 GGGGAAVTVA 30 FTNARDCFLH 40 LPRRLVAQLH 50 LLQNQAIEVV 60 WSHQPAFLSW 70 VEGRHFSDQG 80 ENVAEINRQV 90 GQKLGLSNGG 100 QVFLKPCSHV 110 VSCQQVEVEP 120 LSADDWEILE 130 LHAVSLEQHL 140 LDQIRIVFPK 150 AIFPVWVDQQ 160 TYIFIQIVAL 170 IPAASYGRLE 180 TDTKLLIQPK 190 TRRAKENTFS 200 KADAEYKKLH 210 SYGRDQKGMM 220 KELQTKQLQS 230 NTVGITESNE 240 NESEIPVDSS 250 SVASLWTMIG 260 SIFSFQSEKK 270 QETSWGLTEI 280 NAFKNMQSKV 290 VPLDNIFRVC 300 KSQPPSIYNA 310 SATSVFHKHC 320 AIHVFPWDQE 330 YFDVEPSFTV 340 TYGKLVKLLS 350 PKQQQSKTKQ 360 NVLSPEKEKQ 370 MSEPLDQKKI 380 RSDHNEEDEK 390 ACVLQVVWNG 400 LEELNNAIKY 410 TKNVEVLHLG 420 KVWIPDDLRK 430 RLNIEMHAVV 440 RITPVEVTPK 450 IPRSLKLQPR 460 ENLPKDISEE 470 DIKTVFYSWL 480 QQSTTTMLPL 490 VISEEEFIKL 500 ETKDGLKEFS 510 LSIVHSWEKE 520 KDKNIFLLSP 530 NLLQKTTIQV 540 LLDPMVKEEN 550 SEEIDFILPF 560 LKLSSLGGVN 570 SLGVSSLEHI 580 THSLLGRPLS 590 RQLMSLVAGL 600 RNGALLLTGG 610 KGSGKSTLAK 620 AICKEAFDKL 630 DAHVERVDCK 640 ALRALNDMIK 650 EFISMGSLVA 660 LIATSQSQQS 670 LHPLLVSAQG 680 VHIFQCVQHI 690 QPPNQEQRCE 700 ILCNVIKNKL 710 DCDINKFTDL 720 DLQHVAKETG 730 GFVARDFTVL 740 VDRAIHSRLS 750 RQSISTREKL 760 VLTTLDFQKA 770 LRGFLPASLR 780 SVNLHKPRDL 790 GWDKIGGLHE 800 VRQILMDTIQ 810 LPAKYPELFA 820 NLPIRQRTGI 830 LLYGPPGTGK 840 TLLAGVIARE 850 SRMNFISVKG 860 PELLSKYIGA 870 SEQAVRDIFI 880 RAQAAKPCIL 890 FFDEFESIAP 900 RRGHDNTGVT 910 DRVVNQLLTQ 920 LDGVEGLQGV 930 YVLAATSRPD 940 LIDPALLRPG 950 RLDKCVYCPP 960 PDQVSRLEIL 970 NVLSDSLPLA 980 DDVDLQHVAS 990 VTDSFTGADL 1000 KALLYNAQLE 1010 ALHGMLLSSG 1020 LQDGSSSSDS 1030 DLSLSSMVFL 1040 NHSSGSDDSA 1050 GDGECGLDQS 1060 LVSLEMSEIL 1070 PDESKFNMYR 1080 LYFGSSYESE 1090 LGNGTSSDLS 1100 SQCLSAPSSM 1110 TQDLPGVPGK 1120 DQLFSQPPVL 1130 RTASQEGCQE 1140 LTQEQRDQLR 1150 ADISIIKGRY 1160 RSQSGEDESM 1170 NQPGPIKTRL 1180 AISQSHLMTA 1190 LGHTRPSISE 1200 DDWKNFAELY 1210 ESFQNPKRRK 1220 NQSGTMFRPG QKVTLA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0007031 peroxisome organization
Biological Process GO:0015031 protein transport

Reference

PMID: N/A