Search Results
Overview
| Uniprot ID | A0A0G2JSH9 |
|---|---|
| Protein Name | Peroxiredoxin-2 |
| Gene Name | Prdx2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 196 | DSKEYFSKHN***** |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
Protein Sequence
10
MASGNAHIGK
20
PAPDFTATAV
30
VDGAFKEIKL
40
SDYRGKYVVL
50
FFYPLDFTFV
60
CPTEIIAFSD
70
HAEDFRKLGC
80
EVLGVSVDSQ
90
FTHLAWINTP
100
RKEGGLGPLN
110
IPLLADVTKS
120
LSQNYGVLKN
130
DEGIAYRGLF
140
IIDAKGVLRQ
150
ITVNDLPVGR
160
SVDEALRLVQ
170
AFQYTDEHGE
180
VCPAGWKPGS
190
DTIKPNVDDS
KEYFSKHN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0140824 | thioredoxin-dependent peroxiredoxin activity |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.