Search Results

Overview

Uniprot IDA0A0G2JSI1
Protein Name4-trimethylaminobutyraldehyde dehydrogenase
Gene NameAldh9a1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
330 EIADAFTKEVVRQTQ

Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines

Protein Sequence

10 MFLSAVGPVL 20 TSLLRVPRPA 30 AVAAMSTGTF 40 VVSQPLNYRG 50 GARVEPVDAS 60 GTEKAFEPAT 70 GREIATFKCS 80 GEKEVNLAVE 90 NAKAAFKIWS 100 KKSGLERCQV 110 LLEAARIIKE 120 RRDEIAIMET 130 INNGKSIFEA 140 RLDVDTSWQC 150 LEYYAGLAAS 160 MAGEHIQLPG 170 GSFGYTRREP 180 LGVCLGIGAW 190 NYPFQIACWK 200 SAPALACGNA 210 MIFKPSPFTP 220 VSALLLAEIY 230 TKAGAPNGLF 240 NVVQGGAATG 250 QFLCQHRDVA 260 KVSFTGSVPT 270 GMKIMEMAAK 280 GIKPITLELG 290 GKSPLIIFSD 300 CNMKNAVKGA 310 LLANFLTQGQ 320 VCCNGTRVFV 330 QKEIADAFTK 340 EVVRQTQRIK 350 IGDPLLEDTR 360 MGPLINAPHL 370 ERVLGFVRSA 380 KEQGATVLCG 390 GEPYAPEDPK 400 LKHGYYMTPC 410 ILTNCTDDMT 420 CVKEEIFGPV 430 MSILTFETEA 440 EVLERANDTT 450 FGLAAGVFTR 460 DIQRAHRVAA 470 ELQAGTCYIN 480 NYNVSPVELP 490 FGGYKKSGFG 500 RENGRVTIEY 510 YSQLKTVCVE 520 MGDVESPFEN Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity
Molecular Function GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity
Molecular Function GO:0018467 formaldehyde dehydrogenase (NAD+) activity
Biological Process GO:0045329 carnitine biosynthetic process

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.