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Overview

Uniprot ID	A0A0G2JSR0
Protein Name	Non-selective voltage-gated ion channel VDAC3
Gene Name	Vdac3
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
109	IFVPNTGKKSGKLKA
110	FVPNTGKKSGKLKAS
15	CDLGKAAKDVFNKGY
163	SFDTAKSKLCQNNFA
63	GNLETKYKVCNYGLI

Function

Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations. Involved in male fertility and sperm mitochondrial sheath formation

Protein Sequence

10 MCSTPTYCDL 20 GKAAKDVFNK 30 GYGFGMVKID 40 LKTKSCSGVE 50 FSTSGHAYTD 60 TGKASGNLET 70 KYKVCNYGLI 80 FTQKWNTDNT 90 LGTEISWENK 100 LAEGLKLTVD 110 TIFVPNTGKK 120 SGKLKASYRR 130 DCFSVGSNVD 140 IDFSGPTIYG 150 WAVLAFEGWL 160 AGYQMSFDTA 170 KSKLCQNNFA 180 LGYKAEDFQL 190 HTHVNDGTEF 200 GGSIYQRVNE 210 KIETSINLAW 220 TAGSNNTRFG 230 IAAKYRLDCR 240 TSLSAKVNNA 250 SLIGLGYTQS 260 LRPGVKLTLS 270 ALVDGKNFNA 280 GGHKVGLGFE LEA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0046930	pore complex
Molecular Function	GO:0000166	nucleotide binding
Molecular Function	GO:0015288	porin activity
Molecular Function	GO:0008308	voltage-gated monoatomic anion channel activity

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.