Search Results
Overview
| Uniprot ID | A0A0G2JSS1 |
|---|---|
| Protein Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C |
| Gene Name | Ilkap |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 273 | EERMRIQKAGGNVRD |
Function
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation
Protein Sequence
10
MDLFGDLPEP
20
ERAPRPSAGK
30
EAQEGPVLFE
40
DLPPTSSTDS
50
GSGGPLLFDG
60
LPPAGSGNSG
70
SLATSGSQVV
80
KNEGKGAKRK
90
APEEEKNGGE
100
ELVEKKVCKA
110
SSVIFGLKGY
120
VAERKGEREE
130
MQDAHVILND
140
ITQECNPPSS
150
LITRVSYFAV
160
FDGHGGIRAS
170
KFAAQNLHQN
180
LIRKFPKGDV
190
ISVEKTVKRC
200
LLDTFKHTDE
210
EFLKQASSQK
220
PAWKDGSTAT
230
CVLAVDNILY
240
IANLGDSRAI
250
LCRYNEESQK
260
HAALSLSKEH
270
NPTQYEERMR
280
IQKAGGNVRD
290
GRVLGVLEVS
300
RSIGDGQYKR
310
CGVTSVPDIR
320
RCQLTPNDRF
330
ILLACDGLFK
340
VFTPEEAVNF
350
ILSCLEDEKI
360
QTREGKPAVD
370
ARYEAACNRL
380
ANKAVQRGSA
390
DNVTVMVVRI
GH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.