Search Results
Overview
| Uniprot ID | A0A0G2JSZ5 |
|---|---|
| Protein Name | Protein disulfide-isomerase A6 |
| Gene Name | Pdia6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 165 | RGDSSSKKDVVELTD |
| 240 | LASRYGIKGFPTIKI |
| 246 | IKGFPTIKIFQKGES |
| 250 | PTIKIFQKGESPVDY |
| 78 | KKAASALKDVVKVGA |
| 82 | SALKDVVKVGAVNAD |
Function
May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin
Protein Sequence
10
MRVISMARLV
20
LGLVSCTFFL
30
AVSALYSSSD
40
DVIELTPSNF
50
NREVIQSDSL
60
WLVEFYAPWC
70
GHCQRLTPEW
80
KKAASALKDV
90
VKVGAVNADK
100
HQSLGGQYGV
110
QGFPTIKIFG
120
ANKNKPEDYQ
130
GGRTGEAIVD
140
AALSALRQLV
150
KDRLGGRSGG
160
YSSGKQGRGD
170
SSSKKDVVEL
180
TDDTFDKNVL
190
DSEDVWMVEF
200
YAPWCGHCKN
210
LEPEWAAAAT
220
EVKEQTKGKV
230
KLAAVDATVN
240
QVLASRYGIK
250
GFPTIKIFQK
260
GESPVDYDGG
270
RTRSDIVSRA
280
LDLFSDNAPP
290
PELLEIINED
300
IAKKTCEEHQ
310
LCVVAVLPHI
320
LDTGATGRNS
330
YLEVLLKLAD
340
KYKKKMWGWL
350
WTEAGAQYEL
360
ENALGIGGFG
370
YPAMAAINAR
380
KMKFALLKGS
390
FSEQGINEFL
400
SFLWRTTLTS
VMWSSMT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.