Search Results

Overview

Uniprot ID	A0A0G2JTD7
Protein Name	CLIP-associating protein 1
Gene Name	Clasp1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
286	MASSLGSKSSAAKEG

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMESCLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVVLLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGICLC 160 LIATLNASGA 170 QTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMIQSANDKN 250 FDDEDSVDGN 260 RPSSASSSSS 270 KAPSSSRRNV 280 SMGTTRRLMA 290 SSLGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIVSLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTASR 590 GSTVSTKSMS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVSSSSGS 630 TAFSSAAALP 640 PGSYASLDGT 650 ATKAEGRIRT 660 RRQSSGSTTN 670 VASTSSDSRG 680 RSRAKVVSQS 690 QRSRSANPAG 700 AGSRSSSPGK 710 LLGSGYGGLA 720 GGSSRGPPVT 730 PSSEKRSKIP 740 RSQGCSRETS 750 PNRIGLDRFG 760 LGQSGRIPGS 770 VSAMRVLSTS 780 TDLEAAVADA 790 LLLGDARSKK 800 KPVRRRYEPY 810 GMYSDDDANS 820 DASSVCSERS 830 YGSRNGGIPH 840 YLRQTEDVAE 850 VLNHCASSNW 860 SERKEGLLGL 870 QNLLKSQRTL 880 SRVELKRLCE 890 IFTRMFADPH 900 SKIADSEAEC 910 EDKEGNLFPS 920 EGSCPVSWSM 930 FLETLVDFII 940 IHKDDLQDWL 950 FVLLTQLLKK 960 MGADLLGSVQ 970 AKVQKALDVT 980 RDSFPFDQQF 990 NILMRFIVDQ 1000 TQTPNLKVKV 1010 AILKYIESLA 1020 RQMDPTDFVN 1030 SSETRLAVSR 1040 IITWTTEPKS 1050 SDVRKAAQIV 1060 LISLFELNTP 1070 EFTMLLGALP 1080 KTFQDGATKL 1090 LHNHLKNSSN 1100 AGVGSPSNTI 1110 GRTPSRHPSS 1120 RTSPLTSPTN 1130 CSHGGLSPSR 1140 LWGWSADGLS 1150 KPPPPFSQPN 1160 SIPTAPSHKT 1170 LRRSYSPSML 1180 DYDTENLNSE 1190 EIYSSLRGVT 1200 EAIEKFSFRS 1210 QEDLNEPIKR 1220 DGKKDCDIVS 1230 RDGGAASPAT 1240 EGRGGSEVEG 1250 GRMALDNKTS 1260 LLNTQPPRAF 1270 PGPRAREYNP 1280 YPYSDTINTY 1290 DKTALKEAVF 1300 DDDMEQLRDV 1310 PIDHSDLVAD 1320 LLKELSNHNE 1330 RVEERKGALL 1340 ELLKITREDS 1350 LGVWEEHFKT 1360 ILLLLLETLG 1370 DKDHSIRALA 1380 LRVLREILRN 1390 QPARFKNYAE 1400 LTIMKTLEAH 1410 KDSHKEVVRA 1420 AEEAASTLAS 1430 SIHPEQCIKV 1440 LCPIIQTADY 1450 PINLAAIKMQ 1460 TKVVERITKE 1470 SLLQLLVDII 1480 PGLLQGYDNT 1490 ESSVRKASVF 1500 CLVAIYSVIG 1510 EDLKPHLAQL 1520 TGSKMKLLNL 1530 YIKRAQTTNS 1540 NSSSSSDVST HS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0051494	negative regulation of cytoskeleton organization
Biological Process	GO:1902904	negative regulation of supramolecular fiber organization
Biological Process	GO:0031110	regulation of microtubule polymerization or depolymerization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.