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Overview

Uniprot IDA0A0G2JTL5
Protein NamePyruvate carboxylase, mitochondrial
Gene NamePc
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1091 LNLKELEKDLIDRHG
1189 QLRSILVKDTQAMKE
1208 PKALKDVKGQIGAPM
1223 PGKVIDVKVAAGAKV
533 VKVIAHGKDHPTAAT
847 KDMAGLLKPAACTML

Function

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate

Protein Sequence

10 MASGGGAPSP 20 DFSLGYSPGL 30 QQSSAGELCI 40 LRPMTSGGAV 50 AACGSSNTSS 60 VCSTIRCLAA 70 GTRYIEEEAS 80 TLHQSGNEAV 90 PWHDLTCCHP 100 CFRKKLHETM 110 LKFQTVRGGL 120 RLLGVRRSST 130 APVASPNVRR 140 LEYKPIKKVM 150 VANRGEIAIR 160 VFRACTELGI 170 RTVAVYSEQD 180 TGQMHRQKAD 190 EAYLIGRGLA 200 PVQAYLHIPD 210 IIKVAKENGV 220 DAVHPGYGFL 230 SERADFAQAC 240 QDAGVRFIGP 250 SPEVVRKMGD 260 KVEARAIAIA 270 AGVPVVPGTN 280 SPINSLHEAH 290 EFSNTYGFPI 300 IFKAAYGGGG 310 RGMRVVHSYE 320 ELEENYTRAY 330 SEALAAFGNG 340 ALFVEKFIEK 350 PRHIEVQILG 360 DQYGNILHLY 370 ERDCSIQRRH 380 QKVVEIAPAT 390 HLDPQLRSRL 400 TSDSVKLAKQ 410 VGYENAGTVE 420 FLVDKHGKHY 430 FIEVNSRLQV 440 EHTVTEEITD 450 VDLVHAQIHV 460 SEGRSLPDLG 470 LRQENIRING 480 CAIQCRVTTE 490 DPARSFQPDT 500 GRIEVFRSGE 510 GMGIRLDNAS 520 AFQGAVISPH 530 YDSLLVKVIA 540 HGKDHPTAAT 550 KMSRALAEFR 560 VRGVKTNIPF 570 LQNVLNNQQF 580 LAGIVDTQFI 590 DENPELFQLR 600 PAQNRAQKLL 610 HYLGHVMVNG 620 PTTPIPVKVS 630 PSPVDPIVPV 640 VPIGPPPAGF 650 RDILLREGPE 660 GFARAVRNHQ 670 GLLLMDTTFR 680 DAHQSLLATR 690 VRTHDLKKIA 700 PYVAHNFNNL 710 FSIENWGGAT 720 FDVAMRFLYE 730 CPWRRLQELR 740 ELIPNIPFQM 750 LLRGANAVGY 760 TNYPDNVVFK 770 FCEVAKENGM 780 DVFRIFDSLN 790 YLPNMLLGME 800 AAGSAGGVVE 810 AAISYTGDVA 820 DPSRTKYSLE 830 YYMGLAEELV 840 RAGTHILCIK 850 DMAGLLKPAA 860 CTMLVSSLRD 870 RFPDLPLHIH 880 THDTSGSGVA 890 AMLACAQAGA 900 DVVDVAVDSM 910 SGMTSQPSMG 920 ALVACTKGTP 930 LDTEVPLERV 940 FDYSEYWEGA 950 RGLYAAFDCT 960 ATMKSGNSDV 970 YENEIPGGQY 980 TNLHFQAHSM 990 GLGSKFKEVK 1000 KAYVEANQML 1010 GDLIKVTPSS 1020 KIVGDLAQFM 1030 VQNGLSRAEA 1040 EAQAEELSFP 1050 RSVVEFLQGY 1060 IGIPHGGFPE 1070 PFRSKVLKDL 1080 PRIEGRPGAS 1090 LPPLNLKELE 1100 KDLIDRHGEE 1110 VTPEDVLSAA 1120 MYPDVFAQFK 1130 DFTATFGPLD 1140 SLNTRLFLQG 1150 PKIAEEFEVE 1160 LERGKTLHIK 1170 ALAVSDLNRA 1180 GQRQVFFELN 1190 GQLRSILVKD 1200 TQAMKEMHFH 1210 PKALKDVKGQ 1220 IGAPMPGKVI 1230 DVKVAAGAKV 1240 VKGQPLCVLS 1250 AMKMETVVTS 1260 PMEGTIRKVH 1270 VTKDMTLEGD DLILEIE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0009374 biotin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004736 pyruvate carboxylase activity
Biological Process GO:0019752 carboxylic acid metabolic process
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0044794 host-mediated activation of viral process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0019674 NAD+ metabolic process
Biological Process GO:0006739 NADP+ metabolic process
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0019076 viral release from host cell
Biological Process GO:0019074 viral RNA genome packaging

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.