Overview
| Uniprot ID | A0A0G2JTR4 |
|---|
| Protein Name | Active breakpoint cluster region-related protein |
|---|
| Gene Name | Abr |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 581 |
YDKTKVNKDNNEIVD |
Function
Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity (By similarity)
Protein Sequence
10
MEPLSHRGLP
20
RLSWIDTLYS
30
NFSYGAEDYD
40
AEGHEEQKGP
50
PEGSETMPYI
60
DESPTMSPQL
70
SARSQGGGES
80
ISPTPPEGLA
90
PGVEAGKGLE
100
MRKLVLSGFL
110
ASEEIYINQL
120
EALLLPMKPL
130
KATATTSQPV
140
LTIQQIETIF
150
YKIQDIYEIH
160
KEFYDNLCPK
170
VQQWDSQVTM
180
GHLFQKLASQ
190
LGVYKAFVDN
200
YKVALETAEK
210
CSQSNNQFQK
220
ISEELKVKGP
230
KDSKDSHTSV
240
TMEALLYKPI
250
DRVTRSTLVL
260
HDLLKHTPVD
270
HPDYPLLQDA
280
LRISQNFLSS
290
INEDIDPRRT
300
AVTTPKGETR
310
QLVKDGFLVE
320
MSESSRKLRH
330
VFLFTDVLLC
340
AKLKKTSAGK
350
HQQYDCKWYI
360
PLADLVFPSP
370
EESEASPQVH
380
PFPDHELEDM
390
KVKISALKSE
400
IQKEKANKGQ
410
SRAIERLKKK
420
MFENEFLLLL
430
NSPTIPFRIH
440
NRNGKSYLFL
450
LSSDYERSEW
460
REAIQKLQKK
470
DLQAFVLSSV
480
ELQVLTGSCF
490
KLRTVHNIPV
500
TSNKDDDESP
510
GLYGFLHVIV
520
HSAKGFKQSA
530
NLYCTLEVDS
540
FGYFVSKAKT
550
RVFRDTTEPK
560
WDEEFEIELE
570
GSQSLRILCY
580
EKCYDKTKVN
590
KDNNEIVDKI
600
MGKGQIQLDP
610
QTVESKNWHT
620
DVIEMNGIKV
630
EFSMKFTSRD
640
MSLKRTPSKK
650
QTGVFGVKIS
660
VVTKRERSKV
670
PYIVRQCIEE
680
VEKRGIEEVG
690
IYRISGVATD
700
IQALKAVFDA
710
NNKDILLMLS
720
DMDINAIAGT
730
LKLYFRELPE
740
PLLTDRLYPA
750
FMEGIALSDP
760
AAKENCMMHL
770
LRSLPDPNLI
780
TFLFLLEHLK
790
RVAEKEPINK
800
MSLHNLATVF
810
GPTLLRPSEV
820
ESKAHLTSAA
830
DIWSHDVMAQ
840
VQVLLYYLQH
850
PPISFAELKR
NTLYFSTDV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030424 |
axon |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0099092 |
postsynaptic density, intracellular component |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Biological Process |
GO:0030036 |
actin cytoskeleton organization |
| Biological Process |
GO:0090630 |
activation of GTPase activity |
| Biological Process |
GO:0007420 |
brain development |
| Biological Process |
GO:0042472 |
inner ear morphogenesis |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0050804 |
modulation of chemical synaptic transmission |
| Biological Process |
GO:0060313 |
negative regulation of blood vessel remodeling |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0002692 |
negative regulation of cellular extravasation |
| Biological Process |
GO:0050728 |
negative regulation of inflammatory response |
| Biological Process |
GO:0043314 |
negative regulation of neutrophil degranulation |
| Biological Process |
GO:0050885 |
neuromuscular process controlling balance |
| Biological Process |
GO:0050766 |
positive regulation of phagocytosis |
| Biological Process |
GO:0043114 |
regulation of vascular permeability |
| Biological Process |
GO:0032496 |
response to lipopolysaccharide |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.