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Overview

Uniprot IDA0A0G2JU49
Protein NameMetaxin-1
Gene NameMtx1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
223 KVITEPHKIITHLRK

Function

Involved in transport of proteins into the mitochondrion. Essential for embryonic development

Protein Sequence

10 MRLGGPPRNV 20 RSGQRFERSR 30 CSRGHVQFGK 40 SPQRPLSRTR 50 CPSSKPCLSP 60 AVRGYARQRH 70 RESPKRAWTA 80 ALLPYGGRLR 90 TSPRRSSEGQ 100 CSTSSSAAAS 110 PAARSHASLD 120 LKLRVATQAE 130 TRGCSSWREK 140 ADAYERVLPG 150 QRMCKMAAPM 160 ELFCWSGGWG 170 LPSVDLDSLA 180 VLTYTRFTCA 190 PLKVHKISNP 200 WQSPSDLFNI 210 FSILGTLPAL 220 RTSSGKVITE 230 PHKIITHLRK 240 EKYNADYDLS 250 ARQGADTLAF 260 ISLLEEKLLP 270 MLIHTFWIDA 280 KNYVEVTRKW 290 YAEAMPFPLN 300 FFLPGRMQRR 310 HMERLQLLCG 320 EHRLESEEEL 330 EKELYQEARE 340 CLTLLSHRLG 350 SRKFFFGDAP 360 ASLDAFVFSH 370 LVLLLQAKLP 380 SGKLQAHLRG 390 LQNLCVYCTH 400 ILNLYFPRDA 410 TDVPPPPCQT 420 PAGPETEEEP 430 YRRRTQILSV 440 LAGLAAMVGY 450 ALLSGIVSIQ 460 RASPARAPCT 470 QALDLAEEDE ED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001401 SAM complex
Biological Process GO:0007595 lactation
Biological Process GO:0070096 mitochondrial outer membrane translocase complex assembly
Biological Process GO:0045040 protein insertion into mitochondrial outer membrane
Biological Process GO:0015031 protein transport

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.