Search Results

Overview

Uniprot ID	A0A0G2JU83
Protein Name	Delta(14)-sterol reductase LBR
Gene Name	AABR07021955.1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
58	ESDIKPLKSFKQRKS

Function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane

Protein Sequence

10 MPSRKFAEGE 20 VVRGRWPGSS 30 LYYEVEILSH 40 DNKSQVYTVK 50 YKDGTELELK 60 ESDIKPLKSF 70 KQRKSGSTSS 80 SPSRRRSSRS 90 RSRSRSRSPG 100 RAPKGSRRSV 110 SASYQADAKE 120 KEMRREILQV 130 KLTPLVLKPF 140 ANSVSVYNGE 150 PEHMEKSATP 160 PKNKQVPVPF 170 ALCPSVRLHW 180 NLGPVPLGTF 190 QVTTPQRRDL 200 EFGGVPGALL 210 IMLGLPACVF 220 LLLLQCAQKD 230 PGLLQFPPPL 240 PALRELWEAR 250 VCGVYLLWFF 260 LQALFSLLPV 270 GKVRFLAHEM 280 GSLTFRVGLY 290 AFILTSAAVG 300 TAVFWDIELY 310 YLYTHFLQFA 320 LAAIVFSVVL 330 SVYLYARSLK 340 VPRDELSPAS 350 SGNAVYDFFI 360 GRELNPRIGA 370 FDLKFFCELR 380 PGLIGWVVIN 390 LVMLLAEMKV 400 QERSAPSLAM 410 TLVNSFQLLY 420 VVDALWFEEA 430 LLTTMDIIHD 440 GFGFMLAFGD 450 LVWVPFTYSL 460 QAFYLVNHPQ 470 DLSWPLASVI 480 IALKLCGYVI 490 FRCANSQKNA 500 FRKNPTDPKL 510 AHLKTIPTST 520 GKSLLVSGWW 530 GFVRHPNYLG 540 DLIMALAWSL 550 PCGFNHILPY 560 FYVIYFTALL 570 IHREARDEHQ 580 CRRKYGLAWE 590 KYCQRVPYRI FPYIY

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0005637	nuclear inner membrane
Molecular Function	GO:0050613	Delta14-sterol reductase activity
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006695	cholesterol biosynthetic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.