Search Results
Overview
| Uniprot ID | A0A0G2JU91 |
|---|---|
| Protein Name | Nuclear receptor corepressor 2 |
| Gene Name | Ncor2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | DIEFTESKRPRLELL |
| 1221 | TASGSITKGLPSTRT |
| 1274 | AREDTLPKGHVIYEG |
| 1282 | GHVIYEGKKGHVLSY |
| 1588 | EGSLLSSKASQDRKL |
| 192 | MVEQQISKLKKKQQQ |
| 279 | INQAMRKKLILYFKR |
| 335 | KVREYYEKQFPEIRK |
| 650 | SKTVSQCKNFYFNYK |
| 657 | KNFYFNYKKRQNLDE |
| 670 | DEILQQHKLKMEKER |
| 904 | KVEEAGSKAAVTKGS |
| 963 | RASTSPQKPLDLKQL |
| 968 | PQKPLDLKQLKQRAA |
| 97 | TFLPELGKPDIEFTE |
Function
Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000118 | histone deacetylase complex |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0005112 | Notch binding |
| Molecular Function | GO:0035259 | nuclear glucocorticoid receptor binding |
| Molecular Function | GO:0016922 | nuclear receptor binding |
| Molecular Function | GO:0042974 | nuclear retinoic acid receptor binding |
| Molecular Function | GO:0046965 | nuclear retinoid X receptor binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Biological Process | GO:0021846 | cell proliferation in forebrain |
| Biological Process | GO:0021549 | cerebellum development |
| Biological Process | GO:0008544 | epidermis development |
| Biological Process | GO:0061436 | establishment of skin barrier |
| Biological Process | GO:0044849 | estrous cycle |
| Biological Process | GO:0030900 | forebrain development |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0003007 | heart morphogenesis |
| Biological Process | GO:0001701 | in utero embryonic development |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045599 | negative regulation of fat cell differentiation |
| Biological Process | GO:1902894 | negative regulation of miRNA transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0090312 | positive regulation of protein deacetylation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0060816 | random inactivation of X chromosome |
| Biological Process | GO:0010565 | regulation of ketone metabolic process |
| Biological Process | GO:0032355 | response to estradiol |
| Biological Process | GO:0021537 | telencephalon development |
| Biological Process | GO:0060509 | type I pneumocyte differentiation |
| Biological Process | GO:0050872 | white fat cell differentiation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.