Search Results

Overview

Uniprot IDA0A0G2JU91
Protein NameNuclear receptor corepressor 2
Gene NameNcor2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
106 DIEFTESKRPRLELL
1221 TASGSITKGLPSTRT
1274 AREDTLPKGHVIYEG
1282 GHVIYEGKKGHVLSY
1588 EGSLLSSKASQDRKL
192 MVEQQISKLKKKQQQ
279 INQAMRKKLILYFKR
335 KVREYYEKQFPEIRK
650 SKTVSQCKNFYFNYK
657 KNFYFNYKKRQNLDE
670 DEILQQHKLKMEKER
904 KVEEAGSKAAVTKGS
963 RASTSPQKPLDLKQL
968 PQKPLDLKQLKQRAA
97 TFLPELGKPDIEFTE

Function

Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3. Required to activate the histone deacetylase activity of HDAC3. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation

Protein Sequence

10 MSGSTQPVAQ 20 TWRAAEPRYP 30 PHGISYPVQI 40 ARPHTDVGLL 50 EYQHHPRDYT 60 SHLSPGSIIQ 70 PQRRRPSLLS 80 EFQPGSERSQ 90 ELHLRPESRT 100 FLPELGKPDI 110 EFTESKRPRL 120 ELLPDTLLRP 130 APLLATGQPS 140 GSEDLTKDRS 150 LAGKLEPVSP 160 PSPPHADPEL 170 ELTPSRLSKE 180 ELIQNMDRVD 190 REITMVEQQI 200 SKLKKKQQQL 210 EEEAAKPPEP 220 EKPVSPPPIE 230 SKHRSLVQII 240 YDENRKKAEA 250 AHRILEGLGP 260 QVELPLYNQP 270 SDTRQYHENI 280 KINQAMRKKL 290 ILYFKRRNHA 300 RKQWEQRFCQ 310 RYDQLMEAWE 320 KKVERIENNP 330 RRRAKESKVR 340 EYYEKQFPEI 350 RKQRELQERM 360 QSRVGQRGSG 370 LSMSAARSEH 380 EVSEIIDGLS 390 EQENLEKQMR 400 QLAVIPPMLY 410 DADQQRIKFI 420 NMNGLMDDPM 430 KVYKDRQVTN 440 MWSEQERDTF 450 REKFMQHPKN 460 FGLIASFLER 470 KTVAECVLYY 480 YLTKKNENYK 490 SLVRRSYRRR 500 GKSQQQQQQQ 510 QQQQQQQQQQ 520 QMARSSQEEK 530 EEKEKEKEAD 540 KEEEKQDAEN 550 EKEELSKEKT 560 DDTSGEDNDE 570 KEAVASKGRK 580 TANSQGRRKG 590 RITRSMANEA 600 NHEETATPQQ 610 SSELASMEMN 620 ESSRWTEEEM 630 ETAKKGLLEH 640 GRNWSAIARM 650 VGSKTVSQCK 660 NFYFNYKKRQ 670 NLDEILQQHK 680 LKMEKERNAR 690 RKKKKTPAAA 700 SEETAFPPAA 710 EDEEMEASGA 720 SANEEELAEE 730 AEASQASGNE 740 VPRVGECSGP 750 AAVNNSSDTE 760 SVPSPRTEAT 770 KDAGPKPAST 780 EALPAATQPP 790 VPPPEEPATV 800 PDEPCPAPDA 810 SGPPSPVASP 820 PPAAPPAAVD 830 KDEQDQAATV 840 PQTEDAKEQK 850 SEAEELVIDV 860 GKTEEPEAPE 870 EPPESVKSDH 880 KEETEEEPED 890 KAKGPEAIET 900 VSEAPLKVEE 910 AGSKAAVTKG 920 SSSGATQDSD 930 SSATCSADEV 940 DEPEGGDKGR 950 LLSPRPSLLT 960 PAGDPRASTS 970 PQKPLDLKQL 980 KQRAAAIPPI 990 VTKVHEPPRE 1000 DTVPPKPAPP 1010 VPPPTQHLQP 1020 EGDVSQQSGG 1030 SPRGKCRSPV 1040 PPAEKEAEKA 1050 SFFPAFPAEG 1060 PKLPTEPPRW 1070 TSGLPFPIPP 1080 REVIKTSPHA 1090 ADPSAFSYTP 1100 PGHPLPLGLH 1110 DSARPVLPRP 1120 PISNPPPLIS 1130 SAKHPGVLER 1140 QLGTISQQGM 1150 SVQLRVPHSE 1160 HAKAPMGPLT 1170 MGLPLAVDPK 1180 KLAPFSGVKQ 1190 EQLSPRGQAG 1200 PPESLGVPTA 1210 QETSVLRGTA 1220 LGSTASGSIT 1230 KGLPSTRTAD 1240 GPSYRGSITH 1250 GTPADVLYKG 1260 TISRIVGEDS 1270 PSRLDRARED 1280 TLPKGHVIYE 1290 GKKGHVLSYE 1300 GGMSVSQCSK 1310 EDGRSSSGPP 1320 HETAAPKRTY 1330 DMMEGRVGRT 1340 ITSASIEGLM 1350 GRAIPEQHSP 1360 HLKEQHHIRG 1370 SITQGIPRSY 1380 VEAQEDYLRR 1390 EAKLLKREGT 1400 PPPPPPPRDL 1410 TETYKTRPLD 1420 PLGPLKLKPT 1430 HEGVVATVKE 1440 AGRSIHEIPR 1450 EELRRTPELP 1460 LAPRPLKEGS 1470 ITQGTPLKYD 1480 SGVPSSGSKK 1490 HDVRSIIGSP 1500 GRPFPALHPL 1510 DIMADARALE 1520 RACYEESLKS 1530 RSGTSSGAGG 1540 SITRGAPVVV 1550 PELGKPRQSP 1560 LAYEDHGAPF 1570 TSHLPRGSPV 1580 TTREPTPRLQ 1590 EGSLLSSKAS 1600 QDRKLTSTPR 1610 EIAKSPHSTV 1620 PEHHPHPISP 1630 YEHLLRGVTG 1640 VDLYRGHIPL 1650 AFDPTSIPRG 1660 IPLEAAAAAY 1670 YLPRHLAPSP 1680 TYPHLYPPYL 1690 IRGYPDTAAL 1700 ENRQTIINDY 1710 ITSQQMHHNA 1720 ASAMAQRADM 1730 LRGLSPRESS 1740 LALNYAAGPR 1750 GIIDLSQVPH 1760 LPVLVPPTPG 1770 TPATAIDRLA 1780 YLPTAPPPFS 1790 SRHSSSPLSP 1800 GGPTHLAKPT 1810 ATSSSERERE 1820 RERERDKSIL 1830 TSTTTVEHAP 1840 IWRPGTEQSS 1850 GAGGSSRPAS 1860 HTHQHSPISP 1870 RTQDALQQRP 1880 SVLHNTSMKG 1890 VVTSVEPGTP 1900 TVLRSTSTSS 1910 PVRPAATFPP 1920 ATHCPLGGTL 1930 EGVYPTLMEP 1940 VLLPKETSRV 1950 TRPERPRVDA 1960 GHAFLTKPPA 1970 REPASSPSKS 1980 SEPRSLAPPS 1990 SSHTAIARTP 2000 AKSLAPHHAS 2010 PDLPAPTSAS 2020 DLHREKTQSK 2030 PFSIQELELR 2040 SLGKTTLTAA 2050 TFIDAIITRQ 2060 IAHERGPREG 2070 GSLAIDSPGD 2080 GYHSGAGYSP 2090 DGVEPISPVS 2100 SPSLTHDKGL 2110 SKPLEELEKS 2120 HLEGELRHKQ 2130 PGPMKLSGEA 2140 AHLPHLRPLP 2150 ESQPSSSPLL 2160 QTAPGIKGHQ 2170 RVVTLAQHIS 2180 EVITQDYTRH 2190 HPQQLSGPLP 2200 APLYSFPGAS 2210 CPVLDLRRPP 2220 SDLYLPPPDH 2230 GTPARGSPHS 2240 EGGKRSPEPS 2250 KTVLSSSEDA 2260 IEPVSPPEGM 2270 TEPGHARSTA 2280 YPLLYRDGEQ 2290 GEPRMGSKSP 2300 GNTSQPPAFF 2310 SKLTESNSAM 2320 VKSKKQEINK 2330 KLNTHNRNEP 2340 EYNIGQPGTE 2350 IFNMPAITGA 2360 GLMTCRSQAV 2370 QEHASTNMGL 2380 EAIIRKALMG 2390 KYDQWEEPPP 2400 LGANAFNPLN 2410 ASASLPAAAM 2420 PITTADGRSD 2430 HPLTSPGGGG 2440 KAKVSGRPSS 2450 RKAKSPAPGL 2460 APGDRPPSVS 2470 SVHSEGDCNR 2480 RTPLTNRVWE 2490 DRPSSAGSTP 2500 FPYNPLIMRL 2510 QAGVMASPPP 2520 PGLAAGSGPL 2530 AGPHHAWDEE 2540 PKPLLCSQYE TLSDSE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0005112 Notch binding
Molecular Function GO:0035259 nuclear glucocorticoid receptor binding
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0042974 nuclear retinoic acid receptor binding
Molecular Function GO:0046965 nuclear retinoid X receptor binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0021846 cell proliferation in forebrain
Biological Process GO:0021549 cerebellum development
Biological Process GO:0008544 epidermis development
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0044849 estrous cycle
Biological Process GO:0030900 forebrain development
Biological Process GO:0010467 gene expression
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0001701 in utero embryonic development
Biological Process GO:0007595 lactation
Biological Process GO:0060766 negative regulation of androgen receptor signaling pathway
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045599 negative regulation of fat cell differentiation
Biological Process GO:1902894 negative regulation of miRNA transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0090312 positive regulation of protein deacetylation
Biological Process GO:0050821 protein stabilization
Biological Process GO:0060816 random inactivation of X chromosome
Biological Process GO:0010565 regulation of ketone metabolic process
Biological Process GO:0032355 response to estradiol
Biological Process GO:0021537 telencephalon development
Biological Process GO:0060509 type I pneumocyte differentiation
Biological Process GO:0050872 white fat cell differentiation

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.