Search Results
Overview
| Uniprot ID | A0A0G2JUC7 |
|---|---|
| Protein Name | Dynactin subunit 2 |
| Gene Name | Dctn2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 65 | AYDKFKDKRVGTKGL |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development
Protein Sequence
10
MADPKYADLP
20
GIARNEPDVY
30
ETSDLPEDDQ
40
AEFDAAAVHQ
50
EELSSTSVEH
60
IIVNPNAAYD
70
KFKDKRVGTK
80
GLDFSDRIGK
90
TKRTGYESGD
100
YEMLGEGLGV
110
KETPQQKYQR
120
LLHEVQELTT
130
EVEKIKTTVK
140
ESATEEKLTP
150
VVLAKQLAAL
160
KQQLVASHLE
170
KLLGPDAAIN
180
LADPDGALAK
190
RLLLQLEATK
200
SSKGSSGGKS
210
TGGTPPDSSL
220
VTYELHSRPE
230
QDKFSQAAKV
240
AELEKRLTEL
250
EATVRCDQDA
260
QNPLSAGLQG
270
ACLMETVELL
280
QAKVNALDLA
290
VLDQVEARLQ
300
SVLGKVNEIA
310
KHKASVEDAD
320
TQNKVHQLYE
330
TIQRWSPVAS
340
TLPELVQRLV
350
TIKQLHEQAM
360
QFGQLLTHLD
370
TTQQMMASSL
380
KDNTALLTQV
390
QTTMRENLAT
400
VEGNFASIDA
RMKKLGK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0030286 | dynein complex |
| Biological Process | GO:0007017 | microtubule-based process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.