Overview
| Uniprot ID | A0A0G2JUG7 |
|---|
| Protein Name | IQ motif and SEC7 domain-containing protein 1 |
|---|
| Gene Name | Iqsec1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 933 |
RDLSEAGKRGRRSSA |
Function
Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalization of beta-1 integrin. Involved in neuronal development (By similarity). In neurons, plays a role in the control of vesicle formation by endocytoc cargo. Upon long term depression, interacts with GRIA2 and mediates the activation of ARF6 to internalize synaptic AMPAR receptors (PubMed:20547133)
Protein Sequence
10
MACRRRYLSS
20
LETGSSLSTD
30
RYSVEGEAPS
40
SETGTSLDSP
50
SAYHQGPLVP
60
GSSLSPDHYE
70
HTSVGAYGLY
80
AGPGPQQRTR
90
RPRLQHSTSV
100
LRKQAEEEAI
110
KRSRSLSESY
120
ELSSDLQDKQ
130
VEMLERKYGG
140
RLVTRHAART
150
IQTAFRQYQM
160
NKNFERLRSS
170
MSENRMSRRI
180
VLSNMRMQFS
190
FEGPEKVHSS
200
YFEGKQVSVT
210
NDGSQLGALV
220
PSECGDLSDP
230
ALKSPAPSSD
240
FADAITELED
250
AFSRQVKSLA
260
ESIDDALNCR
270
SLHSEEVPAS
280
DTARARDTEP
290
KPGLHGMDHR
300
KLDEMTASYS
310
DVTLYIDEEE
320
LSPPLPLSQA
330
GDRPSSTESD
340
LRLRSGGAAQ
350
DYWALAHKED
360
KADTDTSCRS
370
TPSLERPEPR
380
LRVEHLPLLT
390
IEPPSDSSVE
400
LSDRSDRSSL
410
KRQSAYERSL
420
GGQQGSPKHG
430
PHGGPPKGLP
440
REEPELRPRP
450
PRPLESHLAI
460
NGSANRQSKS
470
ESDYSDGDND
480
SINSTSNSND
490
TINCSSESSS
500
RDSLREQTLS
510
KQTYHKETRN
520
SWDSPAFSND
530
VIRKRHYRIG
540
LNLFNKKPEK
550
GIQYLIERGF
560
VPDTPVGVAH
570
FLLQRKGLSR
580
QMIGEFLGNR
590
QKQFNRDVLD
600
CVVDEMDFSA
610
MELDEALRKF
620
QAHIRVQGEA
630
QKVERLIEAF
640
SQRYCVCNPG
650
VVRQFRNPDT
660
IFILAFAIIL
670
LNTDMYSPNV
680
KPERKMKLED
690
FVKNLRGVDD
700
GEDIPRETLI
710
GIYERIRKRE
720
LKTNEDHVSQ
730
VQKVEKLIVG
740
KKPIGSLHHG
750
LGCVLSLPHR
760
RLVCYCRLFE
770
VPDPNKPQKL
780
GLHQREIFLF
790
NDLLVVTKIF
800
QKKKNSVTYS
810
FRQSFSLYGM
820
QVLLFENQYY
830
PNGIRLTSAV
840
PGADIKVLIN
850
FNAPNPQDRK
860
KFTDDLRESV
870
AEVQEMEKHR
880
IESELEKQKG
890
VVRPSMSQCS
900
SLKKESGNGT
910
LSRACLDDSY
920
ASGEGLKRSA
930
LSSSLRDLSE
940
AGKRGRRSSA
950
GSLESNVEFQ
960
PFQPSQPPVL
CS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0008021 |
synaptic vesicle |
| Molecular Function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Biological Process |
GO:0060996 |
dendritic spine development |
| Biological Process |
GO:0120183 |
positive regulation of focal adhesion disassembly |
| Biological Process |
GO:0051549 |
positive regulation of keratinocyte migration |
| Biological Process |
GO:0051965 |
positive regulation of synapse assembly |
| Biological Process |
GO:0099170 |
postsynaptic modulation of chemical synaptic transmission |
| Biological Process |
GO:0032012 |
regulation of ARF protein signal transduction |
| Biological Process |
GO:0099149 |
regulation of postsynaptic neurotransmitter receptor internalization |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0098839 |
postsynaptic density membrane |
| Cellular Component |
GO:0099092 |
postsynaptic density, intracellular component |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.