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Overview

Uniprot ID	A0A0G2JUI5
Protein Name	CLIP-associating protein 1
Gene Name	Clasp1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
286	MASSLGSKSSAAKEG

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMESCLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVVLLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGICLC 160 LIATLNASGA 170 QTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMIQSANDKN 250 FDDEDSVDGN 260 RPSSASSSSS 270 KAPSSSRRNV 280 SMGTTRRLMA 290 SSLGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNAVSLKKI 360 RSLLLAGAAE 370 YDNFFQHLRL 380 LDGAFKLSAK 390 DLRSQVVREA 400 CITLGLLTLA 410 STLGVAAAQL 420 CSVCWILNLV 430 TNITKKNCGP 440 RAVFACASMH 450 HTHIPRLIPV 460 ITSNCTSKSV 470 AVRRRCFEFL 480 DLLLQEWQTH 490 SLERHISVLA 500 ETIKKGIHDA 510 DSEARIEARK 520 CYWGFHSHFS 530 REAEHLYHTL 540 ESSYQKALQS 550 HLKNSDSIVS 560 LPQSDRSSSS 570 SQESLNRPLS 580 AKRSPTGSTA 590 SRGSTVSTKS 600 MSTTGSLQRS 610 RSDIDVNAAA 620 SAKSKVSSSS 630 GSTAFSSAAA 640 LPPGSYASLD 650 GTATKAEGRI 660 RTRRQSSGST 670 TNVASTSSDS 680 RGRSRAKVVS 690 QSQRSRSANP 700 AGAGSRSSSP 710 GKLLGSGYGG 720 LAGGSSRGPP 730 VTPSSEKRSK 740 IPRSQGCSRE 750 TSPNRIGLAR 760 SSRIPRPSMS 770 QGCSRDTSRE 780 SSRDTSPARG 790 FTPLDRFGLG 800 QSGRIPGSVS 810 AMRVLSTSTD 820 LEAAVADALL 830 LGDARSKKKP 840 VRRRYEPYGM 850 YSDDDANSDA 860 SSVCSERSYG 870 SRNGGIPHYL 880 RQTEDVAEVL 890 NHCASSNWSE 900 RKEGLLGLQN 910 LLKSQRTLSR 920 VELKRLCEIF 930 TRMFADPHSK 940 VFSMFLETLV 950 DFIIIHKDDL 960 QDWLFVLLTQ 970 LLKKMGADLL 980 GSVQAKVQKA 990 LDVTRDSFPF 1000 DQQFNILMRF 1010 IVDQTQTPNL 1020 KVKVAILKYI 1030 ESLARQMDPT 1040 DFVNSSETRL 1050 AVSRIITWTT 1060 EPKSSDVRKA 1070 AQIVLISLFE 1080 LNTPEFTMLL 1090 GALPKTFQDG 1100 ATKLLHNHLK 1110 NSSNAGVGSP 1120 SNTIGRTPSR 1130 HPSSRTSPLT 1140 SPTNCSHGGL 1150 SPSRLWGWSA 1160 DGLSKPPPPF 1170 SQPNSIPTAP 1180 SHKTLRRSYS 1190 PSMLDYDTEN 1200 LNSEEIYSSL 1210 RGVTEAIEKF 1220 SFRSQEDLNE 1230 PIKRDGKKDC 1240 DIVSRDGGAA 1250 SPATEGRGGS 1260 EVEGGRMALD 1270 NKTSLLNTQP 1280 PRAFPGPRAR 1290 EYNPYPYSDT 1300 INTYDKTALK 1310 EAVFDDDMEQ 1320 LRDVPIDHSD 1330 LVADLLKELS 1340 NHNERVEERK 1350 GALLELLKIT 1360 REDSLGVWEE 1370 HFKTILLLLL 1380 ETLGDKDHSI 1390 RALALRVLRE 1400 ILRNQPARFK 1410 NYAELTIMKT 1420 LEAHKDSHKE 1430 VVRAAEEAAS 1440 TLASSIHPEQ 1450 CIKVLCPIIQ 1460 TADYPINLAA 1470 IKMQTKVVER 1480 ITKESLLQLL 1490 VDIIPGLLQG 1500 YDNTESSVRK 1510 ASVFCLVAIY 1520 SVIGEDLKPH 1530 LAQLTGSKVC IVLPAVACT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0007026	negative regulation of microtubule depolymerization

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.