Overview
| Uniprot ID | A0A0G2JV04 |
|---|
| Protein Name | ADP-ribosylation factor-binding protein GGA3 |
|---|
| Gene Name | Gga3 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 185 |
LAKLLRSKNPDDLQE |
Function
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (By similarity). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (PubMed:26446845)
Protein Sequence
10
MAEAEGESLE
20
SWLNKATNPS
30
NRQEDWEYII
40
GFCDQINKEL
50
EGPQIAVRLL
60
AHKIQSPQEW
70
EAVQALTVLE
80
ACMKNCGRRL
90
HNEVGKFRFL
100
NELIKVVSPK
110
YLGDRVSEKV
120
KAKVIELLFS
130
WTLALPEEAK
140
IKDAYHMLKR
150
QGIVQSDPPI
160
PMDRTLIPSP
170
PPRPKNPVFD
180
DEEKSKLLAK
190
LLRSKNPDDL
200
QEANQLIKSM
210
VKEDEARIQK
220
VTKRLHTLEE
230
VNNNVKLLHE
240
MLLHYSQEFS
250
SEADKELMKE
260
LFDRCENKRR
270
TLFKLASETE
280
DNDNSLGDIL
290
QASDNLSRVI
300
NSYKTIIEGQ
310
IINGEVTTST
320
VPDSEGNSHC
330
GNQGALIDLA
340
ELDTPSSSSP
350
VLAPAPAPPT
360
SGIPILPPPP
370
QTSGPPRSRS
380
SSQAEAPSGP
390
DSTNNALSLL
400
DEELLCLGLS
410
DPAPTAPKES
420
AGNSPWHLFQ
430
NEPSSDLDFF
440
SPRLVSAASC
450
PSEGSLLPPP
460
VSTSSLSQAP
470
LPAAFPAPVV
480
PASAVTHSTG
490
SFTFSSGPAP
500
ALVPKAEPEG
510
PEYPSSSISH
520
RLDALDQLLE
530
EAKVTSGLVK
540
PVSCFSPGPT
550
ASPLLPASTP
560
ARPLLPFSTG
570
PGSPLFQSPA
580
FQSQGSPQKG
590
PELSLASVHV
600
PLESIKPSSA
610
LPVTAYDKNG
620
FRILFHFAKE
630
CPPGRPDVLV
640
VVVSMLNTAP
650
LPVKSIVLQA
660
AVPKSMKVKL
670
QPPSGTELSP
680
FSPIQPPAAI
690
TQVMLLANPM
700
KEKVRLRYKL
710
TFALGEQLST
720
ELGEVDQFPP
VEQWGNL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005769 |
early endosome |
| Cellular Component |
GO:0031901 |
early endosome membrane |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0032991 |
protein-containing complex |
| Cellular Component |
GO:0055037 |
recycling endosome |
| Cellular Component |
GO:0055038 |
recycling endosome membrane |
| Cellular Component |
GO:0005802 |
trans-Golgi network |
| Molecular Function |
GO:0035091 |
phosphatidylinositol binding |
| Molecular Function |
GO:0140318 |
protein transporter activity |
| Molecular Function |
GO:0044877 |
protein-containing complex binding |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Molecular Function |
GO:0043130 |
ubiquitin binding |
| Biological Process |
GO:0032456 |
endocytic recycling |
| Biological Process |
GO:0043001 |
Golgi to plasma membrane protein transport |
| Biological Process |
GO:0006893 |
Golgi to plasma membrane transport |
| Biological Process |
GO:1902430 |
negative regulation of amyloid-beta formation |
| Biological Process |
GO:0045732 |
positive regulation of protein catabolic process |
| Biological Process |
GO:0031648 |
protein destabilization |
| Biological Process |
GO:0034394 |
protein localization to cell surface |
| Biological Process |
GO:0061462 |
protein localization to lysosome |
| Biological Process |
GO:0006622 |
protein targeting to lysosome |
| Biological Process |
GO:0031647 |
regulation of protein stability |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.