Search Results

Overview

Uniprot ID	A0A0G2JVI5
Protein Name	Actin filament-associated protein 1
Gene Name	Afap1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
324	VSKVTGKKITKIIGL
327	VTGKKITKIIGLGKK

Function

Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton

Protein Sequence

10 MEELIVELRL 20 FLELLDHEYL 30 TSTVREKKAV 40 LTNILLRMQS 50 SKGFEVKDHA 60 QKAETNNLPA 70 PPQMPLPEIP 80 QPWLPPDSGP 90 PPLPTSSLPE 100 GYYEEAVPLS 110 PGKAPEYITS 120 NYDSEAMSSS 130 YESYDEEEED 140 GKGKKTRHQW 150 PSEEASMDLV 160 KDAKICAFLL 170 RKKRFGQWTK 180 LLCVIKDTKL 190 LCYKSSKDQQ 200 PQMELPLQGC 210 SITYIPRDSK 220 KKKHELKITQ 230 QGTDPLVLAV 240 QSKEQAEQWL 250 KVIKEAYSGC 260 SGPVDPECSP 270 PPSASVPVNK 280 AELEKKLSSE 290 RPSSDGEGVV 300 ENGVTTCNGK 310 EQAKRKKPSK 320 SEAKGTVSKV 330 TGKKITKIIG 340 LGKKKPSTDE 350 QTSSAEEDVP 360 TCGYLNVLSN 370 SRWRERWCRV 380 KDSKLILHKD 390 RADLKTHIVS 400 IPLRGCEVIP 410 GLDSKHPLTF 420 RLLRNGQEVA 430 VLEASSSEDM 440 GRWIGILLAE 450 TGSSTDPGAL 460 HYDYIDVEMS 470 ANVIQTAKQT 480 FCFMNRRAVS 490 TSPYLGSLSN 500 GYAHPSGTAL 510 HYDDVPCVNG 520 SLKNKKPPAS 530 SNGLPVKGKA 540 PSSQQKKVES 550 AGGVKRTASN 560 AEQYKYGKNR 570 VEADAKRLQS 580 KEEELLKRKE 590 ALRNRLAQLR 600 KERKDLRAAI 610 EVNAGRKTQV 620 ALEDKLKRLE 630 EECKQREAER 640 VSLELELTEV 650 KESLKKALAG 660 GVTLGLAIEP 670 KSGTSSPQSP 680 VFRHRTLENS 690 PISSCDTSDA 700 EGPLPVNSAA 710 VLKKSQPSSS 720 SSPCRGHVLQ 730 KAKEWELKNG T

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0001725	stress fiber
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0017124	SH3 domain binding

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.