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Overview

Uniprot IDA0A0G2JVL6
Protein NameNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
Gene NameNdufa8
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
19 ELKVEEVKVSSAVLK
26 KVSSAVLKAAAHHYG
41 AQCDKTNKEFMLCRW

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Protein Sequence

10 MPGIVELPTL 20 EELKVEEVKV 30 SSAVLKAAAH 40 HYGAQCDKTN 50 KEFMLCRWEE 60 KDPRRCLKEG 70 KLVNGCALNF 80 FRQIKSHCAE 90 PFTEYWTCLD 100 YSSMQLFRHC 110 RKQQAKFDEC 120 VLDKLGWVRP 130 DLGELSKVTK 140 VKTDRPLPEN 150 PYHSRPRPEP 160 SPVIEGDLKP 170 AKHGSRFFFW NV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005758 mitochondrial intermembrane space
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0045271 respiratory chain complex I
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:0006120 mitochondrial electron transport, NADH to ubiquinone

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.