Search Results
Overview
| Uniprot ID | A0A0G2JWE0 |
|---|---|
| Protein Name | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial |
| Gene Name | Pdp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 385 | ERELERLKLEHPKNE |
Function
Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA
Protein Sequence
10
MSISALLSMG
20
RCCCRCCCPR
30
GLWMLSAPCC
40
DDRRMCVCPG
50
PRRIGIPVRT
60
SSLPLFSDAM
70
PAPTQLFFPL
80
VRNCELSRIY
90
GTACYCHHKH
100
LCCSPPYIPQ
110
NRLRYTPHPA
120
YATFCRPREN
130
WWQYTQGRRY
140
ASTPQKFYLT
150
PPQVNSILKA
160
NEYSFKVPEF
170
DGKNVSSILG
180
FDSNQLPANA
190
PIEDRRSAAT
200
CLQTRGMLLG
210
VFDGHAGCAC
220
SQAVSERLFY
230
YIAVSLLPHE
240
TLLEIENAVE
250
SGRALLPILQ
260
WHKHPNDYFS
270
KEASKLYFNS
280
LRTYWQELID
290
LNTGESADID
300
VKEALINAFK
310
RLDNDISLEA
320
QVGDPNSFLN
330
YLVLRVAFSG
340
ATACVAHVDG
350
VDLHVANTGD
360
SRAMLGVQEE
370
DGSWSAVTLS
380
NDHNAQNERE
390
LERLKLEHPK
400
NEAKSVVKQD
410
RLLGLLMPFR
420
AFGDVKFKWS
430
IDLQKRVIES
440
GPDQLNDNEY
450
TKFIPPNYHT
460
PPYLTAEPEV
470
TYHRLRPQDK
480
FLVLATDGLW
490
ETMHRQDVVR
500
IVGEYLTGMH
510
HQQPIAVGGY
520
KVTLGQMHGL
530
LTERRAKMSS
540
VFEDQNAATH
550
LIRHAVGNNE
560
FGAVDHERLS
570
KMLSLPEELA
580
RMYRDDITII
590
VVQFNSHVVG
AYQNQEQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004741 | [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0140176 | positive regulation of pyruvate decarboxylation to acetyl-CoA |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.