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Overview

Uniprot ID	A0A0G2JWJ0
Protein Name	Protein phosphatase 1 regulatory subunit
Gene Name	Ppp1r12a
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
320	PQKTFKNKETLIIEP
818	AYSRGLTKDNEREGE

Function

Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity

Protein Sequence

10 MKMADAKQKR 20 NEQLKRWIGS 30 ETDLEPPVVK 40 RQKTKVKFDD 50 GAVFLAACSS 60 GDTDEVLKLL 70 HRGADINYAN 80 VDGLTALHQA 90 CIDDNVDMVK 100 FLVENGANIN 110 QPDNEGWIPL 120 HAAASCGYLD 130 IAEFLIGQGA 140 HVGAVNSEGD 150 TPLDIAEEEA 160 MEELLQNEVN 170 RQGVDIEAAR 180 KEEERIMLRD 190 ARQWLNSGHI 200 SDVRHAKSGG 210 TALHVAAAKG 220 YTEVLKLLIQ 230 AGYDVNIKDY 240 DGWTPLHAAA 250 HWGKEEACRI 260 LVDNLCDMET 270 VNKVGQTAFD 280 VADEDILGYL 290 EELQKKQNLL 300 HSEKRDKKSP 310 LIESTANMEN 320 NQPQKTFKNK 330 ETLIIEPEKN 340 ASRIESLEQE 350 KADEEEEGKK 360 DESSCSSEED 370 EEDDSESEAE 380 TDKTKPMASV 390 TNAHTASTQA 400 APAAVTTPTL 410 SSNQGTPTSP 420 VKKFPTSTTK 430 ISPKEEERKD 440 ESPASWRLGL 450 RKTGSYGALA 460 EITASKEAQK 470 EKDTAGVIRS 480 ASSPRLSSSL 490 DNKEKEKDNK 500 GTRLAYVAPT 510 IPRRLGSTSD 520 IEEKENRESS 530 NLRTSSSYTR 540 RKWEDDLKKN 550 SSINEGSTYH 560 RSCSFGRRQD 570 DLISCSVPST 580 TSTPTVTSAA 590 GLQKSFLSST 600 STTAKTPPGS 610 SPAGTQSSTS 620 NRLWAEDSTE 630 KEKDSAPTAA 640 TIPVAPTVVS 650 AAASSTTALT 660 TTTAGTLSST 670 SEVRERRRSY 680 LTPVRDEESE 690 SQRKARSRQA 700 RQSRRSTQGV 710 TLTDLQEAEK 720 TIGRSRSTRT 730 REQENEEKDK 740 EEKEKQDKEK 750 QEEKKESEVS 760 REDEYKQKYS 770 RTYDETYARY 780 RPVSTSSSST 790 PSSSSLSTLG 800 SSLYASSQLN 810 RPNSLVGITS 820 AYSRGLTKDN 830 EREGEKKEEE 840 KEGEDKSQPK 850 SIRERRRPRE 860 KRRSTGVSFW 870 TQDSDENEQE 880 RQSDTEDGSS 890 KRDTQTDSVS 900 RYDSSSTSSS 910 DRYDSLLGRS 920 ASYSYLEERK 930 PYGSRLEKDD 940 STDFKKLYEQ 950 ILAENEKLKA 960 QLHDTNMELT 970 DLKLQLEKAT 980 QRQERFADRS 990 LLEMEKRERR 1000 ALERRISEME 1010 EELKMLPDLK 1020 ADNQRLKDEN 1030 GALIRVISKL SK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0001725	stress fiber
Molecular Function	GO:0019208	phosphatase regulator activity
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0007165	signal transduction

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.