Search Results
Overview
| Uniprot ID | A0A0G2JWK2 |
|---|---|
| Protein Name | Methyl-CpG-binding protein 2 |
| Gene Name | Mecp2 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 215 | SPGKLLVKMPFQASP |
| 22 | EKPLKFKKVKKDKKE |
| 24 | PLKFKKVKKDKKEDK |
Function
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC)
Protein Sequence
10
REEKSEDQDL
20
QGLKEKPLKF
30
KKVKKDKKED
40
KEGKHEPLQP
50
SAHHSAEPAE
60
AGKAETSESS
70
GSAPAVPEAS
80
ASPKQRRSII
90
RDRGPMYDDP
100
TLPEGWTRKL
110
KQRKSGRSAG
120
KYDVYLINPQ
130
GKAFRSKVEL
140
IAYFEKVGDT
150
SLDPNDFDFT
160
VTGRGSPSRR
170
EQKPPKKPKS
180
PKAPGTGRGR
190
GRPKGSGTGR
200
PKAAASEGVQ
210
VKRVLEKSPG
220
KLLVKMPFQA
230
SPGGKGEGGG
240
ATTSAQVMVI
250
KRPGRKRKAE
260
ADPQAIPKKR
270
GRKPGSVVAA
280
AAAEAKKKAV
290
KESSIRSVQE
300
TVLPIKKRKT
310
RETVSIEVKE
320
VVKPLLVSTL
330
GEKSGKGLKT
340
CKSPGRKSKE
350
SSPKGRSSSA
360
SSPPKKEHHH
370
HHHHAESPKA
380
PMPLLPPPPP
390
PEPQSSEDPI
400
SPPEPQDLSS
410
SICKEEKMPR
420
AGSLESDGCP
430
KEPAKTQPMV
440
AAAATTTTTT
450
TTTVAEKYKH
460
RGEGERKDIV
470
SSSMPRPNRE
480
EPVDSRTPVT
ERVS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0010385 | double-stranded methylated DNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.