Overview
| Uniprot ID | A0A0G2JWX1 |
|---|
| Protein Name | 26S proteasome non-ATPase regulatory subunit 11 |
|---|
| Gene Name | Psmd11 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 110 |
DILHSIVKRDIQEND |
Function
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity
Protein Sequence
10
MMEWLFVFFL
20
TDGREMAIGS
30
SYAAFGTLLV
40
HPLRRETTTP
50
GVLGEGRRGL
60
RVGTRGLVFR
70
VCVSGVGGRG
80
RGRCESGKMA
90
AAAVVEFQRA
100
QSLLSTDREA
110
SIDILHSIVK
120
RDIQENDEEA
130
VQVKEQSILE
140
LGSLLAKTGQ
150
AAELGGLLKY
160
VRPFLNSISK
170
AKAARLVRSL
180
LDLFLDMEAA
190
TGQEVELCLE
200
CIEWAKSEKR
210
TFLRQALEAR
220
LVSLYFDTKR
230
YQEALHLGSQ
240
LLRELKKMDD
250
KALLVEVQLL
260
ESKTYHALSN
270
LPKARAALTS
280
ARTTANAIYC
290
PPKLQATLDM
300
QSGIIHAAEE
310
KDWKTAYSYF
320
YEAFEGYDSI
330
DSPKAITSLK
340
YMLLCKIMLN
350
TPEDVQALVS
360
GKLALRYAGR
370
QTEALKCVAQ
380
ASKNRSLADF
390
EKALTDYRAE
400
LRDDPIISTH
410
LAKLYDNLLE
420
QNLIRVIEPF
430
SRVQIEHISS
440
LIKLSKADVE
450
RKLSQMILDK
460
KFHGILDQGE
470
GVLIIFDEPP
480
VDKTYEAALE
490
TIQNMSKVVD
500
SLYNKAKKLT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005838 |
proteasome regulatory particle |
| Biological Process |
GO:0043248 |
proteasome assembly |
| Biological Process |
GO:0048863 |
stem cell differentiation |
| Biological Process |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.