Search Results
Overview
| Uniprot ID | A0A0G2JXR7 |
|---|---|
| Protein Name | Spliceosome-associated protein CWC27 homolog |
| Gene Name | Cwc27 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 230 | QSMKGRSKSSHDLLK |
Function
As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs
Protein Sequence
10
MSNIYIQEPP
20
TNGKVLLKTT
30
AGDIDIELWS
40
KEAPKACRNF
50
IQLCLEAYYD
60
NTIFHRVVPG
70
FIVQGGDPTG
80
TGTGGESVYG
90
APFKDEFHSR
100
LRFNRRGLVA
110
MANAGPHDNG
120
SQFFFTLGRA
130
DELNNKHTIF
140
GKVTGDTVYN
150
MLRLTEVDID
160
DEERPRNPHR
170
IKSCEVLFNP
180
FDDIIPREIK
190
KPKKEKAEEE
200
IKKLKPKGTK
210
NFSLLSFGEE
220
AEEEEEEVNR
230
VSQSMKGRSK
240
SSHDLLKDDP
250
HLSSVPAVES
260
EKDDATGDLE
270
DLSQDAEDDS
280
VEHDGSMEED
290
EKNLMRERIA
300
KRLKKDASAN
310
VKSAGDGEKK
320
PASRSEELRK
330
EARQLKRELL
340
AAKQKKESAT
350
KAEKGSEEEE
360
AVPDGPVAEY
370
RREKQKYEAL
380
RKQQPKKGTS
390
REDQTLALLS
400
QFKSKLTQAI
410
TEMPENCAEA
420
EVEDDEGWMS
430
HVLQFEDKTR
440
KVKDASMQDS
450
DTFEIYDPRN
460
PVNKRRREES
470
KKLLREKKER
R
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0071013 | catalytic step 2 spliceosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0071005 | U2-type precatalytic spliceosome |
| Molecular Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Biological Process | GO:0006457 | protein folding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.