Overview
| Uniprot ID | A0A0G2JZ95 |
|---|
| Protein Name | High mobility group protein B1 |
|---|
| Gene Name | Hmgb1 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 82 |
MKTYIPPKGETKKKF |
| 90 |
GETKKKFKDPNAPKR |
Function
In the cytoplasm proposed to dissociate the BECN1:BCL2 complex via competitive interaction with BECN1 leading to autophagy activation. Can protect BECN1 and ATG5 from calpain-mediated cleavage and thus proposed to control their proautophagic and proapoptotic functions and to regulate the extent and severity of inflammation-associated cellular injury. In myeloid cells has a protective role against endotoxemia and bacterial infection by promoting autophagy. Involved in endosomal translocation and activation of TLR9 in response to CpG-DNA in macrophages
Protein Sequence
10
MGKGDPKKPR
20
GKMSSYAFFV
30
QTCREEHKKK
40
HPDASVNFSE
50
FSKKCSERWK
60
TMSAKEKGKF
70
EDMAKADKAR
80
YEREMKTYIP
90
PKGETKKKFK
100
DPNAPKRPPS
110
AFFLFCSEYR
120
PKIKGEHPGL
130
SIGDVAKKLG
140
EMWNNTAADD
150
KQPYEKKAAK
160
LKEKYEKVRR
170
MAGNLVGDCT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0005793 |
endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component |
GO:0005768 |
endosome |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0008201 |
heparin binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0002250 |
adaptive immune response |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0048468 |
cell development |
| Biological Process |
GO:0071345 |
cellular response to cytokine stimulus |
| Biological Process |
GO:0006935 |
chemotaxis |
| Biological Process |
GO:0006310 |
DNA recombination |
| Biological Process |
GO:0006281 |
DNA repair |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0010508 |
positive regulation of autophagy |
| Biological Process |
GO:0045597 |
positive regulation of cell differentiation |
| Biological Process |
GO:0032722 |
positive regulation of chemokine production |
| Biological Process |
GO:0032732 |
positive regulation of interleukin-1 production |
| Biological Process |
GO:0032755 |
positive regulation of interleukin-6 production |
| Biological Process |
GO:0032760 |
positive regulation of tumor necrosis factor production |
| Biological Process |
GO:0051052 |
regulation of DNA metabolic process |
| Biological Process |
GO:0032496 |
response to lipopolysaccharide |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.