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Overview

Uniprot ID	A0A0G2JZA2
Protein Name	GrpE protein homolog
Gene Name	Grpel1
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
107	NLRQRSQKLVEEAKL
228	PALVGVVKDA*****
71	TDPSSADKTLLEEKV
85	VKLEEQLKETMEKYK

Function

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins

Protein Sequence

10 MWHTLILTHL 20 KRHPHSLGGV 30 CDVSTLGRPK 40 VNIRPSPRLL 50 CTATKQKNNG 60 QNLEEDLGHC 70 EPKTDPSSAD 80 KTLLEEKVKL 90 EEQLKETMEK 100 YKRALADTEN 110 LRQRSQKLVE 120 EAKLYGIQGF 130 CKDLLEVADI 140 LEKATQSVPK 150 EEVSNNNPHL 160 KSLYEGLVMT 170 EVQIQKVFTK 180 HGLLRLDPIG 190 AKFDPYEHEA 200 LFHTPVEGKE 210 PGTVALVSKV 220 GYKLHGRTLR 230 PALVGVVKDA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Molecular Function	GO:0000774	adenyl-nucleotide exchange factor activity
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0051087	protein-folding chaperone binding
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:0006457	protein folding

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.