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Overview

Uniprot ID	A0A0G2JZZ7
Protein Name	Active breakpoint cluster region-related protein
Gene Name	Abr
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
544	YDKTKVNKDNNEIVD

Function

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity

Protein Sequence

10 MEEEEEAIGF 20 LDKVLEDEDV 30 FLLEECELGT 40 PTSPGSGSPF 50 LVAVKVEAGK 60 GLEMRKLVLS 70 GFLASEEIYI 80 NQLEALLLPM 90 KPLKATATTS 100 QPVLTIQQIE 110 TIFYKIQDIY 120 EIHKEFYDNL 130 CPKVQQWDSQ 140 VTMGHLFQKL 150 ASQLGVYKAF 160 VDNYKVALET 170 AEKCSQSNNQ 180 FQKISEELKV 190 KGPKDSKDSH 200 TSVTMEALLY 210 KPIDRVTRST 220 LVLHDLLKHT 230 PVDHPDYPLL 240 QDALRISQNF 250 LSSINEDIDP 260 RRTAVTTPKG 270 ETRQLVKDGF 280 LVEMSESSRK 290 LRHVFLFTDV 300 LLCAKLKKTS 310 AGKHQQYDCK 320 WYIPLADLVF 330 PSPEESEASP 340 QVHPFPDHEL 350 EDMKVKISAL 360 KSEIQKEKAN 370 KGQSRAIERL 380 KKKMFENEFL 390 LLLNSPTIPF 400 RIHNRNGKSY 410 LFLLSSDYER 420 SEWREAIQKL 430 QKKDLQAFVL 440 SSVELQVLTG 450 SCFKLRTVHN 460 IPVTSNKDDD 470 ESPGLYGFLH 480 VIVHSAKGFK 490 QSANLYCTLE 500 VDSFGYFVSK 510 AKTRVFRDTT 520 EPKWDEEFEI 530 ELEGSQSLRI 540 LCYEKCYDKT 550 KVNKDNNEIV 560 DKIMGKGQIQ 570 LDPQTVESKN 580 WHTDVIEMNG 590 IKVEFSMKFT 600 SRDMSLKRTP 610 SKKQTGVFGV 620 KISVVTKRER 630 SKVPYIVRQC 640 IEEVEKRGIE 650 EVGIYRISGV 660 ATDIQALKAV 670 FDANNKDILL 680 MLSDMDINAI 690 AGTLKLYFRE 700 LPEPLLTDRL 710 YPAFMEGIAL 720 SDPAAKENCM 730 MHLLRSLPDP 740 NLITFLFLLE 750 HLKRVAEKEP 760 INKMSLHNLA 770 TVFGPTLLRP 780 SEVESKAHLT 790 SAADIWSHDV 800 MAQVQVLLYY 810 LQHPPISFAE 820 LKRNTLYFST DV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030424	axon
Cellular Component	GO:0043197	dendritic spine
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0099092	postsynaptic density, intracellular component
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity
Biological Process	GO:0035556	intracellular signal transduction

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.