Search Results
Overview
| Uniprot ID | A0A0G2K012 |
|---|---|
| Protein Name | UBX domain-containing protein 6 |
| Gene Name | Ubxn6 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 116 | SAGEKTSKGKSPQLA |
Function
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes
Protein Sequence
10
MLSCPPPPPG
20
GCRGPEGEPV
30
VLATASADRK
40
MAPRPRGAAR
50
RLSRVPGGTS
60
VAEIFSFRWL
70
AACSSPTRAL
80
RPPPRGPRRR
90
AAAMKKFFQE
100
IKADIKFKSA
110
GPGQKLTDSA
120
GEKTSKGKSP
130
QLALRQPRQG
140
PTDEAQMAAA
150
AALARLEQKQ
160
PRARGPTSQD
170
SIRNQVRKEL
180
QAEATSSNNP
190
GAPGTNSVPE
200
TKDEISPHLA
210
VPGVFFICPL
220
TGVTLRRDQR
230
DAHIKQAILS
240
HFSTDPVAAS
250
IMKIHTFNRD
260
RDRVKLGVDT
270
IAKYLDNIHL
280
HPEEEKYQKI
290
KLQNKVFQER
300
INCLEGSHEF
310
FEAIGFKKVT
320
LPVPDQEGQE
330
FYVLGEDARA
340
QPQNLERHKQ
350
QLLGAEPVRA
360
TLDRQLRVFR
370
PSALASHFEL
380
PSDFFSLTAE
390
EVKREQRLRT
400
EAVERLSSLR
410
TKAMREKEEQ
420
RELRKYTYAL
430
LRVRLPDGCL
440
LQGTFYAREK
450
LSVLFQFVRE
460
ALQNDWLPFE
470
LRASGGQKLE
480
ENEALALNEC
490
GLVPSALLTF
500
SWDASVLEDI
510
RAAGAEPAKS
520
VLRPELLAAI
EQLS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:1904949 | ATPase complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0051117 | ATPase binding |
| Biological Process | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:0016236 | macroautophagy |
| Biological Process | GO:0000423 | mitophagy |
| Biological Process | GO:0043335 | protein unfolding |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.