Overview
| Uniprot ID | A0A0G2K038 |
|---|
| Protein Name | Oligoribonuclease, mitochondrial |
|---|
| Gene Name | Rexo2 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 103 |
WCKEHHGKSGLTKAV |
Function
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development
Protein Sequence
10
MLGVSLGARL
20
LRGVGGRRGQ
30
FGARGVSEGS
40
AAMAAGESMA
50
QRMVWVDLEM
60
TGLDIEKDQI
70
IEMACLITDS
80
DLNILAEGPN
90
LIIKQPDELL
100
DSMSDWCKEH
110
HGKSGLTKAV
120
KESTVTLQQA
130
EYEFLSFVRQ
140
QTPPGLCPLA
150
GNSVHADKKF
160
LDKHMPQFMK
170
HLHYRIIDVS
180
TVKELCRRWY
190
PEDYEFAPKK
200
AASHRALDDI
210
SESIKELQFY
220
RNNIFKKKTD
230
EKKRKIIENG
240
ENEKPLTLHL
250
QTPPADETSL
FRSF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005758 |
mitochondrial intermembrane space |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0008296 |
3'-5'-DNA exonuclease activity |
| Molecular Function |
GO:0000175 |
3'-5'-RNA exonuclease activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0003676 |
nucleic acid binding |
| Biological Process |
GO:2000827 |
mitochondrial RNA surveillance |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.