Search Results
Overview
| Uniprot ID | A0A0G2K059 |
|---|---|
| Protein Name | Calcium uniporter protein |
| Gene Name | Mcu |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 315 | KSRFDLEKYNQLKDA |
Function
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways
Protein Sequence
10
MAAAAGRSLL
20
LLLCSRGGGG
30
GAGGCGALTA
40
GCFPGLGVSR
50
QRPHQQHRTA
60
HQRPASWQSV
70
GAAYCSTVVP
80
SDDVTVVYQN
90
GLPVISVRLP
100
SRRERCQFTL
110
KPISDSVGVF
120
LRQLQEEDRG
130
IDRVAIYSPD
140
GVRVAASTGI
150
DLLLLDDFKL
160
VINDLTYHVR
170
PPKRDLLSHE
180
NAETLNDVKT
190
LVQQLYTTLC
200
IEQHQLNKER
210
ELVERLEDLR
220
QQLAPLEKVR
230
IEISRKAEKR
240
TTLVLWGGLA
250
YMATQFGILA
260
RLTWWEYSWD
270
IMEPVTYFIT
280
YGSAMAMYAY
290
FVMTRQEYVY
300
PEARDRQYLL
310
FFHKGAKKSR
320
FDLEKYNQLK
330
DAIAQKWILR
D
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034704 | calcium channel complex |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:1990246 | uniplex complex |
| Molecular Function | GO:0005262 | calcium channel activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0015292 | uniporter activity |
| Biological Process | GO:0036444 | calcium import into the mitochondrion |
| Biological Process | GO:0019722 | calcium-mediated signaling |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0072732 | cellular response to calcium ion starvation |
| Biological Process | GO:0006091 | generation of precursor metabolites and energy |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0051560 | mitochondrial calcium ion homeostasis |
| Biological Process | GO:0006851 | mitochondrial calcium ion transmembrane transport |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0032024 | positive regulation of insulin secretion |
| Biological Process | GO:0051561 | positive regulation of mitochondrial calcium ion concentration |
| Biological Process | GO:0090141 | positive regulation of mitochondrial fission |
| Biological Process | GO:0090023 | positive regulation of neutrophil chemotaxis |
| Biological Process | GO:0051259 | protein complex oligomerization |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.