Overview
| Uniprot ID | A0A0G2K0D7 |
|---|
| Protein Name | Proteasome subunit alpha type-6 |
|---|
| Gene Name | Psma6 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 26 |
TSVAVRGKDCAVIVT |
| 83 |
RYEAANWKYKYGYEI |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MANLRKKYAF
20
KAINQGGLTS
30
VAVRGKDCAV
40
IVTQKKVPDK
50
LLDSSTVTHL
60
FKITENIGCV
70
MTGMTADSRS
80
QVQRARYEAA
90
NWKYKYGYEI
100
PVDMLCKRIA
110
DISQVYTQNA
120
EMRPLGCCMI
130
LIGIDEEQGP
140
QVYKCDPAGY
150
YCGFKATAAG
160
VKQTESTSFL
170
EKKVKKKFDW
180
TFEQTVETAI
190
TCLSTVLSID
200
FKPSEIEVGV
210
VTVENPKFSC
GFLPFAF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Biological Process |
GO:0051603 |
proteolysis involved in protein catabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.