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Overview

Uniprot IDA0A0G2K0J4
Protein NameNipped-B protein
Gene NameNipbl
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
1363 GGGLLSSKAKRAKCS
2568 YSPSESAKVYDKAIN
603 HPETPKNKSDPELSK
948 GGRSSALKNFVIPKI

Function

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner. Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others

Protein Sequence

10 MNGDMPHVPI 20 TTLAGIASLT 30 DLLNQLPLPS 40 PLPATTTKSL 50 LFNSRIAEEV 60 NCLLACRDDN 70 LVSQLVHSLN 80 QVSTDHIELK 90 DNLGSDDPEG 100 DIPVLLQAVL 110 ARSPNVFREK 120 SMQNRYVQSG 130 MMMSQYKLSQ 140 NSMHSSPASS 150 NYQQTTISHS 160 PSSRFVPPQT 170 SSGNRFMPQQ 180 NSPVPSPYAP 190 QSPAGYMPYS 200 HPSSYTTHPQ 210 MQQASVSSPI 220 VAGGLRNIHD 230 NKVSGPLSGN 240 SANHHADNPR 250 HGSSDDYLHM 260 VHRLSSDDGD 270 SSAMRNAASF 280 PLRSPQPVCS 290 PAGSDGTPKG 300 SRPPLILQSQ 310 SLPCSSPRDV 320 PPDILLDSPE 330 RKQKKQKKMK 340 LGKDEKDQNE 350 KAAMYDIISS 360 PTKDSTKLTL 370 RLSRVRSSDM 380 DQQEDMLSGM 390 ENSNVSENDI 400 PFNVQYPGQT 410 SKTPITPQDV 420 NRSLNAAQCL 430 SQQEQTAFLP 440 ANQVPVLQQN 450 TSVATKQPQT 460 SVVQNQQQVS 470 QQGPIYDEVE 480 LDALAEIERI 490 ERESAIERER 500 FSKEVQDKDK 510 PLKKRKQDSY 520 PQEAGGATGG 530 NRPASQETGS 540 TGNGSRPALM 550 VSIDLHQAGR 560 ADSQASLTQD 570 SDNIKKPEET 580 KQCNDAPISV 590 LQEDSVGSLK 600 SIPENHPETP 610 KNKSDPELSK 620 SEMKQNESRL 630 SESKPNENQL 640 GESKSNESKL 650 ETKTETQTEE 660 LKQSENKTTE 670 SKQSESAVVE 680 PKQNENRLCD 690 TKPNDNKQNN 700 TRSENTKARP 710 ETPKQKAESR 720 PETPKQKSEG 730 RPETPKQKGD 740 GRPETPKQKS 750 EGRPETPKQK 760 GEGRPETPKH 770 RHENRKDSGK 780 PSTEKKPDVS 790 KHKQDIKSDS 800 SRLKSERAEA 810 LKQRPDGRSE 820 SLRRDHDSKQ 830 KSDDRGESER 840 HRGDQSRVRR 850 PETLRSSSRN 860 EHSTKSDGSK 870 TEKLERKHRH 880 ESGDSRDRPS 890 GEQKSRPDSP 900 RVKQGDTNKS 910 RPGFKSPNSK 920 DDKRTEGNRS 930 KVDSNKAHTD 940 NKAEFPSYLL 950 GGRSSALKNF 960 VIPKIKRDKD 970 GNITQETKKM 980 DMKGEQKDKV 990 EKMGLVEDLN 1000 KGAKPVVVLQ 1010 KLSLDDVQKL 1020 IKDREEKSRS 1030 SLKSLKNKPS 1040 KSNKGSIDQS 1050 VLKELPPELL 1060 AEIESTMPLC 1070 ERVKMNKRKR 1080 STVNEKPKYA 1090 EISSDEDNDS 1100 DEAFESSRKR 1110 HKKDDDKAWE 1120 YEERDRRSSG 1130 DHRRSGHSHD 1140 GRRSSGGGRY 1150 RNRSPSDSDM 1160 EDYSPPPSLS 1170 EVARKMKKKE 1180 KQKKRKAYEP 1190 KLTPEEMMDS 1200 STFKRFTASI 1210 ENILDNLEDM 1220 DFTAFGDDDE 1230 IPQELLLGKH 1240 QLNELGSESA 1250 KIKAMGIMDK 1260 LSTDKTVKVL 1270 NILEKNIQDG 1280 SKLSTLLNHN 1290 NDTEEEERLW 1300 RDLIMERVTK 1310 SADACLTTIN 1320 IMTSPNMPKA 1330 VYIEDVIERV 1340 IQYTKFHLQN 1350 TLYPQYDPVY 1360 RLDPHGGGLL 1370 SSKAKRAKCS 1380 THKQRVIVML 1390 YNKVCDIVSS 1400 LSELLEIQLL 1410 TDTTILQVSS 1420 MGITPFFVEN 1430 VSELQLCAIK 1440 LVTAVFSRYE 1450 KHRQLILEEI 1460 FTSLARLPTS 1470 KRSLRNFRLN 1480 SSDVDGEPMY 1490 IQMVTALVLQ 1500 LIQCVVHLPS 1510 SEKDPNSEED 1520 SNKKVDQDVV 1530 ITNSYETAMR 1540 TAQNFLSIFL 1550 KKCGSKQGEE 1560 DYRPLFENFV 1570 QDLLSTVNKP 1580 EWPAAELLLS 1590 LLGRLLVHQF 1600 SNKSTEMALR 1610 VASLDYLGTV 1620 AARLRKDAVT 1630 SKMDQGSIER 1640 ILKQVSGGED 1650 EIQQLQKALL 1660 DYLDENTETD 1670 PSLVFSRKFY 1680 IAQWFRDTTL 1690 ETEKAMKSQK 1700 DEESSDGAHH 1710 AKEIETTGQI 1720 MHRAESRKRF 1730 LRSIIKTTPS 1740 QFSTLKMNSD 1750 TVDYDDACLI 1760 VRYLASMRPF 1770 AQSFDIYLTQ 1780 ILRVLGENAI 1790 AVRTKAMKCL 1800 SEVVAVDPSI 1810 LARLDMQRGV 1820 HGRLMDNSTS 1830 VREAAVELLG 1840 RFVLCRPQLA 1850 EQYYDMLIER 1860 ILDTGISVRK 1870 RVIKILRDIC 1880 IEQPTFPKIT 1890 EMCVKMIRRV 1900 NDEEGIKKLV 1910 NETFQKLWFT 1920 PTPHNDKEAM 1930 TRKILNITDV 1940 VAACRDTGYD 1950 WFEQLLQNLL 1960 KSEEDSSYKP 1970 VKKACTQLVD 1980 NLVEHILKYE 1990 ESLADSDNKG 2000 VNSGRLVACI 2010 TTLFLFSKIR 2020 PQLMVKHAMT 2030 MQPYLTTKCS 2040 TQNDFMVICN 2050 VAKILELVVP 2060 LMEHPSETFL 2070 ATIEEDLMKL 2080 IIKYGMTVVQ 2090 HCVSCLGAVV 2100 NKVTQNFKFV 2110 WACFNRYYGA 2120 ISKLKSQHQE 2130 DPNNTSLLTN 2140 KPALLRSLFT 2150 VGALCRHFDF 2160 DLEDFKGNSK 2170 VNIKDKVLEL 2180 LMYFTKHSDE 2190 EVQTKAIIGL 2200 GFAFIQHPSL 2210 MFEQEVKNLY 2220 NSILSDKNSS 2230 VNLKIQVLKN 2240 LQTYLQEEDT 2250 RMQQADRDWK 2260 KVAKQEDLKE 2270 MGDVSSGMSS 2280 SIMQLYLKQV 2290 LEAFFHTQSS 2300 VRHFALNVIA 2310 LTLNQGLIHP 2320 VQCVPYLIAM 2330 GTDPEPAMRN 2340 KADQQLVEID 2350 KKYAGFIHMK 2360 AVAGMKMSYQ 2370 VQQAINTCLK 2380 DPVRGFRQDE 2390 SSSALCSHLY 2400 SMIRGNRQHR 2410 RAFLISLLNL 2420 FDDTAKTEVT 2430 MLLYIADNLA 2440 CFPYQTQEEP 2450 LFIMHHIDIT 2460 LSVSGSNLLQ 2470 SFKESMVKDK 2480 RKERKTSPAK 2490 ENESSESEEE 2500 VCRPRKSRKR 2510 VDSESDSDSE 2520 DDVNSVMKCL 2530 PENSAPLIEF 2540 ANVSQGILLL 2550 LMLKQHLKNL 2560 CGFSDSKIQK 2570 YSPSESAKVY 2580 DKAINRKTGV 2590 HFHPKQTLDF 2600 LRSDMANSKL 2610 TEDVKRSIVR 2620 QYLDFKLLME 2630 HLDPDEEEEE 2640 GEVSASTNAR 2650 NKAITSLLGG 2660 GSPKNNPAAD 2670 TEDEESDGED 2680 RGGGTSGSLR 2690 RSKRNSDSTE 2700 LAAQMNESVD 2710 VMDVIAICCP 2720 KYKDRPQIAR 2730 VVQRTSSGVS 2740 VQWMAGSYSG 2750 SWTEAKRRDG 2760 RKLVPWVDTI 2770 KESDIIYKKI 2780 ALTSANKLTN 2790 KVVQTLRSLY AAKDGTSS

Gene Ontology

Classification GO ID Description
Biological Process GO:0034088 maintenance of mitotic sister chromatid cohesion
Cellular Component GO:0000785 chromatin
Cellular Component GO:0032039 integrator complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0090694 Scc2-Scc4 cohesin loading complex
Cellular Component GO:0032116 SMC loading complex
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0070087 chromo shadow domain binding
Molecular Function GO:0061775 cohesin loader activity
Molecular Function GO:0042826 histone deacetylase binding
Molecular Function GO:0036033 mediator complex binding
Molecular Function GO:1990841 promoter-specific chromatin binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0007420 brain development
Biological Process GO:0071481 cellular response to X-ray
Biological Process GO:0140588 chromatin looping
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0050890 cognition
Biological Process GO:0048589 developmental growth
Biological Process GO:0006974 DNA damage response
Biological Process GO:0042471 ear morphogenesis
Biological Process GO:0048701 embryonic cranial skeleton morphogenesis
Biological Process GO:0048557 embryonic digestive tract morphogenesis
Biological Process GO:0035115 embryonic forelimb morphogenesis
Biological Process GO:0048703 embryonic viscerocranium morphogenesis
Biological Process GO:0035261 external genitalia morphogenesis
Biological Process GO:0048592 eye morphogenesis
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0045444 fat cell differentiation
Biological Process GO:0035136 forelimb morphogenesis
Biological Process GO:0061010 gallbladder development
Biological Process GO:0007507 heart development
Biological Process GO:0003007 heart morphogenesis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0007064 mitotic sister chromatid cohesion
Biological Process GO:0000070 mitotic sister chromatid segregation
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0003151 outflow tract morphogenesis
Biological Process GO:0040018 positive regulation of multicellular organism growth
Biological Process GO:2001224 positive regulation of neuron migration
Biological Process GO:0045778 positive regulation of ossification
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0048638 regulation of developmental growth
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0042634 regulation of hair cycle
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0007605 sensory perception of sound
Biological Process GO:0019827 stem cell population maintenance
Biological Process GO:0061038 uterus morphogenesis

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.