Search Results
Overview
| Uniprot ID | A0A0G2K151 |
|---|---|
| Protein Name | Apolipoprotein E |
| Gene Name | Apoe |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 220 | QKRLAVYKAGAQEGA |
| 299 | QMEEVRSKMEEQTQQ |
Function
No function data available.
Protein Sequence
10
MCCHICCQAL
20
LGGFSYCHPL
30
SNSWEWEPLC
40
RRHFSKHPSD
50
WPITTGKMKA
60
LWALLLVPLL
70
TGCLAEGELE
80
VTDQLPGQSD
90
QPWEQALNRF
100
WDYLRWVQTL
110
SDQVQEELQS
120
SQVTQELTVL
130
MEDTMTEVKA
140
YKKELEEQLG
150
PVAEETRARL
160
AKEVQAAQAR
170
LGADMEDLRN
180
RLGQYRNEVN
190
TMLGQSTEEL
200
RSRLSTHLRK
210
MRKRLMRDAD
220
DLQKRLAVYK
230
AGAQEGAERG
240
VSAIRERLGP
250
LVEQGRQRTA
260
NLGAGAAQPL
270
RDRAQALSDR
280
IRGRLEEVGN
290
QARDRLEEVR
300
EQMEEVRSKM
310
EEQTQQIRLQ
320
AEIFQARIKG
330
WFEPLVEDMQ
340
RQWANLMEKI
350
QASVATNSIA
STTVPLENQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034360 | chylomicron remnant |
| Molecular Function | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity |
| Molecular Function | GO:0005543 | phospholipid binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0070326 | very-low-density lipoprotein particle receptor binding |
| Biological Process | GO:0042982 | amyloid precursor protein metabolic process |
| Biological Process | GO:0071402 | cellular response to lipoprotein particle stimulus |
| Biological Process | GO:0033344 | cholesterol efflux |
| Biological Process | GO:0042632 | cholesterol homeostasis |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0034382 | chylomicron remnant clearance |
| Biological Process | GO:0055089 | fatty acid homeostasis |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0034380 | high-density lipoprotein particle assembly |
| Biological Process | GO:0034384 | high-density lipoprotein particle clearance |
| Biological Process | GO:0034375 | high-density lipoprotein particle remodeling |
| Biological Process | GO:0044794 | host-mediated activation of viral process |
| Biological Process | GO:0071831 | intermediate-density lipoprotein particle clearance |
| Biological Process | GO:0042158 | lipoprotein biosynthetic process |
| Biological Process | GO:0035641 | locomotory exploration behavior |
| Biological Process | GO:0015909 | long-chain fatty acid transport |
| Biological Process | GO:0007616 | long-term memory |
| Biological Process | GO:0032438 | melanosome organization |
| Biological Process | GO:1902430 | negative regulation of amyloid-beta formation |
| Biological Process | GO:0043537 | negative regulation of blood vessel endothelial cell migration |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045541 | negative regulation of cholesterol biosynthetic process |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:1900272 | negative regulation of long-term synaptic potentiation |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:0010544 | negative regulation of platelet activation |
| Biological Process | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0050709 | negative regulation of protein secretion |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0038060 | nitric oxide-cGMP-mediated signaling |
| Biological Process | GO:0033700 | phospholipid efflux |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0090205 | positive regulation of cholesterol metabolic process |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0046889 | positive regulation of lipid biosynthetic process |
| Biological Process | GO:1903002 | positive regulation of lipid transport across blood-brain barrier |
| Biological Process | GO:0140077 | positive regulation of lipoprotein transport |
| Biological Process | GO:0032805 | positive regulation of low-density lipoprotein particle receptor catabolic process |
| Biological Process | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:1902995 | positive regulation of phospholipid efflux |
| Biological Process | GO:0017038 | protein import |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:1905906 | regulation of amyloid fibril formation |
| Biological Process | GO:1900221 | regulation of amyloid-beta clearance |
| Biological Process | GO:2000822 | regulation of behavioral fear response |
| Biological Process | GO:0032489 | regulation of Cdc42 protein signal transduction |
| Biological Process | GO:1905890 | regulation of cellular response to very-low-density lipoprotein particle stimulus |
| Biological Process | GO:0061136 | regulation of proteasomal protein catabolic process |
| Biological Process | GO:0043254 | regulation of protein-containing complex assembly |
| Biological Process | GO:0090207 | regulation of triglyceride metabolic process |
| Biological Process | GO:0061771 | response to caloric restriction |
| Biological Process | GO:0043691 | reverse cholesterol transport |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Biological Process | GO:0034447 | very-low-density lipoprotein particle clearance |
| Biological Process | GO:0034372 | very-low-density lipoprotein particle remodeling |
| Biological Process | GO:0019068 | virion assembly |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0034364 | high-density lipoprotein particle |
| Cellular Component | GO:0034363 | intermediate-density lipoprotein particle |
| Cellular Component | GO:0034362 | low-density lipoprotein particle |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0097487 | multivesicular body, internal vesicle |
| Cellular Component | GO:0043083 | synaptic cleft |
| Cellular Component | GO:0034361 | very-low-density lipoprotein particle |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0016209 | antioxidant activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0043395 | heparan sulfate proteoglycan binding |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0005319 | lipid transporter activity |
| Molecular Function | GO:0050750 | low-density lipoprotein particle receptor binding |
| Molecular Function | GO:0046911 | metal chelating activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.