Search Results
Overview
| Uniprot ID | A0A0G2K191 |
|---|---|
| Protein Name | Tubulin-specific chaperone E |
| Gene Name | Tbce |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | DEKSCSLKVGSKQVQ |
| 138 | CSLKVGSKQVQTIGF |
Function
Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network
Protein Sequence
10
MCAQTHTLNN
20
KNLLKQKERS
30
PILNSCYLRM
40
SDILPLDVIG
50
RRVEVNGEYA
60
TVRFCGAVPP
70
VAGLWLGVEW
80
DNPERGKHDG
90
SHEGTMYFKC
100
RHPTGGSFVR
110
PNIVNFGEDF
120
LTALKKRYVL
130
TDGPDDDEKS
140
CSLKVGSKQV
150
QTIGFEHITK
160
KQSQLRSLQD
170
ISLWKCAVSC
180
AGERGRIAEA
190
CPNIRVVDLS
200
KNLLSTWDEV
210
ILIAEQLKDL
220
EALDLSENKL
230
QFPSDSPTLT
240
RTFSTLKTLV
250
LNKTGITWTE
260
VLHCAPSWPV
270
LQELYLKSNG
280
ISISERPVNA
290
LQNLRLLDLS
300
SNPSIDESQL
310
CLIAYLPRLE
320
HLLLSDIGLS
330
SIHFPDAEIG
340
CKTSMFPALT
350
YLIVNDNQIS
360
EWSFINELDK
370
LQSLQALSCA
380
RNPLTKGDKA
390
EEIIIAKIGQ
400
LKTLNRCQIL
410
PEERRGAELD
420
YRKAFGKEWR
430
KAGGHPDPDR
440
NRPSAEFLSA
450
HPRYQLLCCK
460
YGAPEDEELK
470
TQQPFMLKNQ
480
LLTLKIKCSN
490
QPEQQILEKQ
500
LPDSMTIQKV
510
KGLLSRLLKV
520
PVSELLLSYE
530
SSKMPGREIE
540
LENDLQPLQF
550
YSVENGDCLL
VRW
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0006457 | protein folding |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.