Search Results

Overview

Uniprot IDA0A0G2K261
Protein NameIsoleucine--tRNA ligase, mitochondrial
Gene NameIars2
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
241 GLVYRSYKPVYWSPS
661 HGFTLGEKGEKMSKS
687 SGGKDHSKEPPYGAD
775 TKVTDSYKQYDFGKV

Function

Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile))

Protein Sequence

10 MLWGLHPHGP 20 GTAALTAAGS 30 LWGPARFPSR 40 LGCLGMTRRL 50 VVRSVAGADS 60 PQSSPKSGRY 70 RDTVLLPQTN 80 FPMKLLGHQQ 90 SDMELEIQQK 100 CGFSELYSWQ 110 RERKVKTEFC 120 LHDGPPYANG 130 DPHVGHALNK 140 ILKDIVNRFH 150 MMRGSKVHFV 160 PGWDCHGLPI 170 ETKVLSELGV 180 NTQTLSAMEI 190 REKARSFAQA 200 AIEKQKSAFA 210 RWGVMADWSN 220 CYYTFDPKYE 230 AKQLRVFQQM 240 YEKGLVYRSY 250 KPVYWSPSSR 260 TALAEAELEY 270 NPEHVSRSVY 280 VRFPLLKPPP 290 TLESLTGASS 300 PVSALVWTTQ 310 PWTVPANQAI 320 CYMPEAKYAV 330 VKCSASGNFY 340 ILAEDKISPV 350 ASALETTFDV 360 TATFSGVDLE 370 GGTCSHPLIP 380 DKVSPLLPAT 390 HVTMAKGTGL 400 VHTAPAHGME 410 DYSVASQHSL 420 PMDCLVDEEG 430 MFTSAAGPEL 440 QNKAVLTEGT 450 DVVIKMLQAT 460 KNLLKEESIV 470 HSYPCDWRTK 480 KPVLIRASKQ 490 WFVNIMDIKA 500 TAKESLKTVK 510 FIPGAALNSM 520 MDMLDRRPYW 530 CISRQRVWGV 540 PIPVFHHKTK 550 DEYLINSQTT 560 EHIIKLVEQH 570 GSDVWWTLPA 580 EKLLPEEVVA 590 QAGGPGALEY 600 VPGQDILDIW 610 FDSGTSWSCV 620 LQGTEQRADL 630 YLEGKDQLGG 640 WFQSSLLTSV 650 ATRSKAPFRT 660 VMVHGFTLGE 670 KGEKMSKSLG 680 NVIDPDTIIS 690 GGKDHSKEPP 700 YGADILRWWI 710 AESNVFTEVT 720 IGPSVLSAAR 730 DDISKLRNTL 740 RFLLGNLAGF 750 NPETASVPVK 760 NMYIIDQYML 770 HLIQDFATKV 780 TDSYKQYDFG 790 KVVRLLKAFY 800 TRELSSFYFS 810 IVKDRLYCES 820 ETDPKRRSCQ 830 TALAEILDVL 840 VRSFAPVLPH 850 LAEEVFQHIP 860 YVKEPKSVFR 870 TGWISTSSVW 880 KKPGLEEAVE 890 SACAMRDSFL 900 GSIPGKNAAE 910 YDVIIVIEPG 920 LLFEIMEMLQ 930 AEETSSTSQL 940 NELMMASQTT 950 LLAQEPRERS 960 ADAIELTGTF 970 VINLEGQNLT 980 RVRIVEGRRA LGRSVQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0002161 aminoacyl-tRNA deacylase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004822 isoleucine-tRNA ligase activity
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006428 isoleucyl-tRNA aminoacylation
Biological Process GO:0032543 mitochondrial translation

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.