Search Results
Overview
| Uniprot ID | A0A0G2K2P5 |
|---|---|
| Protein Name | Tight junction protein ZO-1 |
| Gene Name | Tjp1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1005 | DPAKVYRKEPYPEEM |
| 1020 | MRQNHILKQPALGHP |
| 1183 | PYAPAGPKSSEPKQY |
| 194 | VTLVKSRKNEEYGLR |
| 257 | ERSKGKLKMVVQRDE |
Function
TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9707407). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting Cdc42bpb to the leading edge of migrating cells (By similarity). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (By similarity). With Tjp2 and Tjp3, participates in the junctional retention and stability of the transcription factor Dbpa, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity)
Protein Sequence
10
MSARAAAAKS
20
TAMEETAIWE
30
QHTVTLHRAP
40
GFGFGIAISG
50
GRDNPHFQSG
60
ETSIVISDVL
70
KGGPAEGQLQ
80
ENDRVAMVNG
90
VSMDNVEHAF
100
AVQQLRKSGK
110
NAKITIRRKK
120
KVQIPVSHPD
130
PDPVSDNEDD
140
SYDEDVHDPR
150
SGRGALANRR
160
GEKSWARDRS
170
ASRDRSLSPR
180
SDRRSVASSQ
190
PAKPTKVTLV
200
KSRKNEEYGL
210
RLASHIFVKE
220
ISQDSLAARD
230
GNIQEGDVVL
240
KINGTVTENM
250
SLTDAKTLIE
260
RSKGKLKMVV
270
QRDERATLLN
280
VPDLSDSIHS
290
ANASERDDIS
300
EIQSLASDHS
310
VRSHDRPPRR
320
SQSRSPDQRS
330
EPSDHSTQSP
340
QQPSNGSLRS
350
REEERMSKPG
360
AVSTPVKHVD
370
DHTPKAVEEV
380
TVEKHEKQTP
390
TLPEPKPVYA
400
QVGQPDVDLP
410
VSPSDGVLPN
420
STHEDGILRP
430
SMKLVKFRKG
440
DSVGLRLAGG
450
NDVGIFVAGV
460
LEDSPAAKEG
470
LEEGDQILRV
480
NNVDFTNIIR
490
EEAVLFLLDL
500
PKGEEVTILA
510
QKKKDVYRRI
520
VESDVGDSFY
530
IRTHFEYEKE
540
SPYGLSFNKG
550
EVFRVVDTLY
560
NGKLGSWLAI
570
RIGKNHKEVE
580
RGIVPNKNRA
590
EQLASVQYTL
600
PKTAGGDRAD
610
FWRFRGLRSS
620
KRNLRKSRED
630
LSAQPVQTKF
640
PAYERVVLRE
650
AGFLRPVTIF
660
GPIADVAREK
670
LAREEPDIYQ
680
IAKSEPRDAG
690
TDHRSSGIIR
700
LHTIKQIIDQ
710
DKHALLDVTP
720
NAVDRLNYAQ
730
WYPIVVFLNP
740
DSKQGVKTMR
750
MRLCPESRKS
760
ARKLYERSHK
770
LRKNNHHLFT
780
TTINLNSMND
790
GWYGALKEAI
800
QQQQNQLVWV
810
SEGKADGATS
820
DDLDLHDDRL
830
SYLSAPGSEY
840
SMYSTDSRHT
850
SDYEDTDTEG
860
GAYTDQELDE
870
TLNDEVGTPP
880
ESAITRSSEP
890
VREDSSGMHH
900
ENQTYPPYSP
910
QAQPQAIHRI
920
DSPGLKTASQ
930
QKAEASSPVP
940
YLSPETNPAS
950
SASAVKHNVN
960
LTNVNLEEPT
970
PAPPTSHVSQ
980
ADCLGAPSPE
990
APHTMLRDEG
1000
VSLPSHVDPA
1010
KVYRKEPYPE
1020
EMMRQNHILK
1030
QPALGHPGQR
1040
LDKEPNPAYD
1050
PQLPYVEKQA
1060
SRDLEQPPYR
1070
YESSSYTDQF
1080
SRNYDHRLRF
1090
EDRVPTYEDQ
1100
WSYYDDKQPY
1110
PTRPFDTQHP
1120
RDLDSRQHPE
1130
EASERGYFQR
1140
FEEPAPLPYD
1150
SRPRYEQLPR
1160
TSTLRHEEQP
1170
TSGYEVHNRY
1180
RPEAQPYAPA
1190
GPKSSEPKQY
1200
FDQYPRSYEQ
1210
VPPPGFTSKT
1220
GHYEPLHGAA
1230
VVPPLIPSSQ
1240
HKPEVLPSAT
1250
KPQPPPPALT
1260
EEEEDPAMKP
1270
QSVLTRVKMF
1280
ENKRSASLEN
1290
KKDVNDTASF
1300
KPPEVASKPP
1310
SASLVGPKPV
1320
SQTQFSEHDK
1330
TLYRLPEPQK
1340
PQAKPPEDIV
1350
RSNHYDPEED
1360
EEYYRKQLSY
1370
FDRRSFESKP
1380
PAHIPAGHHS
1390
EPAKPVHSQS
1400
QPNFSSYSSK
1410
GKPETDAMDR
1420
SFSEKRYDPT
1430
QAMPPPPPLP
1440
SQYSQPVPPL
1450
SNSSLHIHSK
1460
AAQSEGNSVS
1470
LDFQNSYISK
1480
PDPPPSQSKP
1490
ATFRPPTRED
1500
PPQTFYPQKS
1510
FPDKASVNGA
1520
EQTQKTITPA
1530
YNRFTPKPYT
1540
SSARPFERKF
1550
ESPKFNHNLL
1560
PSETVHKPEL
1570
SSKPPPSPKT
1580
LMKAHSSTQP
1590
PEFDSGVETF
1600
SVHTDKPKYQ
1610
INNISTMPKA
1620
VPVSPSAVEE
1630
DEDEDGHTVV
1640
ATARGIFNSN
1650
GGVLSSIETG
1660
VSIIIPQGAI
1670
PEGIEQEIYF
1680
KVCRDNSILP
1690
PLDKEKGETL
1700
LSPLVMCGPH
1710
GLKFLKPVEL
1720
RLPHCASMTP
1730
DGWSFALKSS
1740
DSSSGDPKTW
1750
QNKCLPGDPN
1760
YLVGANCVSV
LIDHF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0043296 | apical junction complex |
| Cellular Component | GO:0045177 | apical part of cell |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016327 | apicolateral plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005921 | gap junction |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0046581 | intercellular canaliculus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0070160 | tight junction |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008013 | beta-catenin binding |
| Molecular Function | GO:0050839 | cell adhesion molecule binding |
| Molecular Function | GO:0071253 | connexin binding |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0031032 | actomyosin structure organization |
| Biological Process | GO:0034334 | adherens junction maintenance |
| Biological Process | GO:0036305 | ameloblast differentiation |
| Biological Process | GO:0070830 | bicellular tight junction assembly |
| Biological Process | GO:0001825 | blastocyst formation |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0045216 | cell-cell junction organization |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0090557 | establishment of endothelial intestinal barrier |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:0043116 | negative regulation of vascular permeability |
| Biological Process | GO:1905605 | positive regulation of blood-brain barrier permeability |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin |
| Biological Process | GO:1903672 | positive regulation of sprouting angiogenesis |
| Biological Process | GO:0071896 | protein localization to adherens junction |
| Biological Process | GO:1902396 | protein localization to bicellular tight junction |
| Biological Process | GO:0150105 | protein localization to cell-cell junction |
| Biological Process | GO:2000810 | regulation of bicellular tight junction assembly |
| Biological Process | GO:1901888 | regulation of cell junction assembly |
| Biological Process | GO:0051493 | regulation of cytoskeleton organization |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0032496 | response to lipopolysaccharide |
| Biological Process | GO:0071000 | response to magnetism |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007605 | sensory perception of sound |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.