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Overview

Uniprot IDA0A0G2K2S2
Protein NameSolute carrier family 2, facilitated glucose transporter member 1
Gene NameSlc2a1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
208 TRDLQEMKEEGRQMM

Function

Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation

Protein Sequence

10 WEPKVTGRLM 20 LAVGGAVLGS 30 LQFGYNTGVI 40 NAPQKVIEEF 50 YNQTWNHRYG 60 ESIPSTTLTT 70 LWSLSVAIFS 80 VGGMIGSFSV 90 GLFVNRFGRR 100 NSMLMMNLLA 110 FVSAVLMGFS 120 KLGKSFEMLI 130 LGRFIIGVYC 140 GLTTGFVPMY 150 VGEVSPTALR 160 GALGTLHQLG 170 IVVGILIAQV 180 SQSGPFPTLR 190 HPTFPPVPPV 200 LKKLRGTADV 210 TRDLQEMKEE 220 GRQMMREKKV 230 TILELFRSPA 240 YRQPILIAVV 250 LQLSQQLSGI 260 NAVFYYSTSI 270 FEKAGVQQPV 280 YATIGSGIVN 290 TAFTVVSLFV 300 VERAGRRTLH 310 LIGLAGMAGC 320 AVLMTIALAL 330 LEQLPWMSYL 340 SIVAIFGFVA 350 FFEVGPGPIP 360 WFIVAELFSQ 370 GPRPAAVAVA 380 GFSNWTSNFI 390 VGMCFQYVEQ 400 LCGPYVFIIF 410 TVLLVLFFIF 420 TYFKVPETKG 430 RTFDEIASGF 440 RQGGASQSDK 450 TPEELFHPLG ADSQV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001917 photoreceptor inner segment
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0055056 D-glucose transmembrane transporter activity
Biological Process GO:1904659 D-glucose transmembrane transport

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.