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Overview

Uniprot IDA0A0G2K3H5
Protein NamePaired amphipathic helix protein Sin3a
Gene NameSin3a
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
440 TGATPPVKKKPKLIS
442 ATPPVKKKPKLISLK
449 KPKLISLKESSMADA

Function

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression. Required for cortical neuron differentiation and callosal axon elongation

Protein Sequence

10 MKRRLDDQES 20 PVYAAQQRRI 30 PGSTEAFSHQ 40 HRVLAPAPPV 50 YEAVSETMQS 60 ATGIQYSVAP 70 NYQVSAVPQS 80 SGSHGPAIAA 90 VHSSHHHPAA 100 VQPHGGQVVQ 110 SHAHPAPSVA 120 PVQGQQQFQR 130 LKVEDALSYL 140 DQVKLQFGSQ 150 PQVYNDFLDI 160 MKEFKSQSID 170 TPGVISRVSQ 180 LFKGHPDLIM 190 GFNTFLPPGY 200 KIEVQTNDMV 210 NVTTPGQVHQ 220 IPTHGIQPQP 230 QPPPQHPSQP 240 SAQSAPTPAQ 250 PAPQPTPAKV 260 SKPSQLQAHT 270 PASQQTPPLP 280 PYASPRSPPV 290 QPHTPVTISL 300 GTAPSLQNNQ 310 PVEFNHAINY 320 VNKIKNRFQG 330 QPDIYKAFLE 340 ILHTYQKEQR 350 NAKEAGGNYT 360 PALTEQEVYA 370 QVARLFKNQE 380 DLLSEFGQFL 390 PDANSSVLLS 400 KTTAEKVDSV 410 RNDHGGTVKK 420 PQLNNKPQRP 430 SQNGCQIRRH 440 SGTGATPPVK 450 KKPKLISLKE 460 SSMADASKHG 470 VGTESLFFDK 480 VRKALRSAEA 490 YENFLRCLVI 500 FNQEVISRAE 510 LVQLVSPFLG 520 KFPELFNWFK 530 NFLGYKESVH 540 LESFPKERAT 550 EGIAMEIDYA 560 SCKRLGSSYR 570 ALPKSYQQPK 580 CTGRTPLCKE 590 VSSLLCSGVR 600 PDHLLLLFFC 610 FKLDVVLETN 620 LATIRVLEAI 630 QKKLSRLSAE 640 EQAKFRLDNT 650 LGGTSEVIHR 660 KALQRIYADK 670 AADIIDGLRK 680 NPSIAVPIVL 690 KRLKMKEEEW 700 REAQRGFNKV 710 WREQNEKYYL 720 KSLDHQGINF 730 KQNDTKVLRS 740 KSLLNEIESI 750 YDERQEQATE 760 ENAGVPVGPH 770 LSLAYEDKQI 780 LEDAAALIIH 790 HVKRQTGIQK 800 EDKYKIKQIM 810 HHFIPDLLFA 820 QRGDLSDVEE 830 EEEEEMDVDE 840 ATGAPKKHNG 850 VGGSPPKSKL 860 LFSNTAAQKL 870 RGMDEVYNLF 880 YVNNNWYIFM 890 RLHQILCLRL 900 LRICSQAERQ 910 IEEENREREW 920 EREVLGIKRD 930 KSDSPAIQLR 940 LKEPMDVDVE 950 DYYPAFLDMV 960 RSLLDGNIDS 970 SQYEDSLREM 980 FTIHAYIAFT 990 MDKLIQSIVR 1000 QLQHIVSDEV 1010 CVQVTDLYLA 1020 ENNNGATGGQ 1030 LSSQTSRSLL 1040 ESTYQRKAEQ 1050 LMSDENCFKL 1060 MFIQSQGQVQ 1070 LTIELLDTEE 1080 ENSDDPVEAE 1090 RWSDYVERYM 1100 SSDTTSPELR 1110 EHLAQKPVFL 1120 PRNLRRIRKC 1130 QRGREQQEKE 1140 GKEGNSKKTM 1150 ENVESLDKLE 1160 CRFKLNSYKM 1170 VYVIKSEDYM 1180 YRRTALLRAH 1190 QSHERVSKRL 1200 HQRFQAWVDK 1210 WTKEHVPREM 1220 AAETSKWLMG 1230 EGLEGLVPCT 1240 TTCDTETLHF 1250 VSIKKYRVKY GTVFKAP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0051726 regulation of cell cycle
Biological Process GO:0048511 rhythmic process

Reference

[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.