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Overview

Uniprot ID	A0A0G2K3U1
Protein Name	AMP deaminase
Gene Name	Ampd2
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
101	PDILLRAKQDFLKTD

Function

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle

Protein Sequence

10 MASEARSGLG 20 ASPLQSARSL 30 PGTAPCLKHF 40 PLDLRTSMDG 50 KCKEIAEELF 60 SRSLAESELR 70 SAPYEFPEES 80 PIEQLEERRQ 90 RLERQISQDV 100 KLEPDILLRA 110 KQDFLKTDSD 120 SDLQLYKEQG 130 EGQGDRGLWE 140 RDVVLEREFQ 150 RVIISGEEKC 160 GVPFTDLLDA 170 AKSVVRALFI 180 REKYMALSLQ 190 SFCPTTRRYL 200 QQLAEKPLET 210 RTYEQSPDTP 220 VSADAPVHPP 230 ALEQHPYEHC 240 EPSTMPGDLG 250 LGLRMVRGVV 260 HVYTRRDPDE 270 HCPEVELPYP 280 DLQEFVADVN 290 VLMALIINGP 300 IKSFCYRRLQ 310 YLSSKFQMHV 320 LLNEMKELAA 330 QKKVPHRDFY 340 NIRKVDTHIH 350 ASSCMNQKHL 360 LRFIKRAMKR 370 HLEEIVHVEQ 380 GREQTLREVF 390 ESMNLTAYDL 400 SVDTLDVHAD 410 RNTFHRFDKF 420 NAKYNPIGES 430 VLREIFIKTD 440 NKISGKYFAH 450 IIKEVMSDLE 460 ESKYQNAELR 470 LSIYGRSRDE 480 WDKLARWAVN 490 HRVHSPNVRW 500 LVQVPRLFDV 510 YRTKGQLANF 520 QEMLENIFLP 530 LFEATVHPAS 540 HPELHLFLEH 550 VDGFDSVDDE 560 SKPENHVFNL 570 ESPLPEAWVE 580 EDNPPYAYYL 590 YYTFANMAML 600 NHLRRQRGFH 610 TFVLRPHCGE 620 AGPIHHLVSA 630 FMLAENISHG 640 LLLRKAPVLQ 650 YLYYLAQIGI 660 AMSPLSNNSL 670 FLSYHRNPLP 680 EYLSRGLMVS 690 LSTDDPLQFH 700 FTKEPLMEEY 710 SIATQVWKLS 720 SCDMCELARN 730 SVLMSGFSHK 740 VKSHWLGPNY 750 TKEGPEGNDI 760 RRTNVPDIRV 770 GYRYETLCQE 780 LALITQAVQS 790 EMLETIPEEV GIVMSPGP

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003876	AMP deaminase activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0097009	energy homeostasis
Biological Process	GO:0032264	IMP salvage

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.