Search Results

Overview

Uniprot IDA0A0G2K3Z9
Protein NamePeroxiredoxin-1
Gene NamePrdx1l1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
136 GLFIIDDKGILRQIT
168 QAFQFTDKHGEVCPA
178 EVCPAGWKPGSDTIK
190 TIKPDVNKSKEYFSK
192 KPDVNKSKEYFSKQK
197 KSKEYFSKQK*****
35 DISLSDYKGKYVVFF
7 *MSSGNAKIGHPAPS
93 AWINTPKKQGGLGPM

Function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation

Protein Sequence

10 MSSGNAKIGH 20 PAPSFKATAV 30 MPDGQFKDIS 40 LSDYKGKYVV 50 FFFYPLDFTF 60 VCPREIIAFS 70 DRAEEFKKLN 80 CQVIGASVDS 90 HFCHLAWINT 100 PKKQGGLGPM 110 NIPLVSDPKR 120 TIAQDYGVLK 130 ADEGISFRGL 140 FIIDDKGILR 150 QITINDLPVG 160 RSVDEILRLV 170 QAFQFTDKHG 180 EVCPAGWKPG 190 SDTIKPDVNK SKEYFSKQK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0008379 thioredoxin peroxidase activity
Biological Process GO:0045454 cell redox homeostasis
Biological Process GO:0042744 hydrogen peroxide catabolic process
Biological Process GO:0045321 leukocyte activation
Biological Process GO:0019430 removal of superoxide radicals
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.