Search Results
Overview
| Uniprot ID | A0A0G2K405 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type II-alpha regulatory subunit |
| Gene Name | Prkar2a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 209 | TYDILVTKDNQTRSV |
| 299 | IVDVIGEKIYKDGER |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
Protein Sequence
10
MSHIQIPPGL
20
TELLQGYTVE
30
VLRQQPPDLV
40
DFAVEYFTRL
50
REARRQESDS
60
FIAPPTTFHA
70
QESSGVPVIE
80
EDGESESDSD
90
DEDLEVPIPS
100
KFTRRVSVCA
110
ETFNPDEEED
120
NDPRVVHPKT
130
DEQRCRLQEA
140
CKDILLFKNL
150
DQHLTRRFQG
160
MSVHVLHQRG
170
WHTVEQLSQV
180
LDAMFEKIVK
190
TDEHVIDQGD
200
DGDNFYVIER
210
GTYDILVTKD
220
NQTRSVGQYD
230
NRGSFGELAL
240
MYNTPRAATI
250
VATSDGSLWG
260
LDRVTFRRII
270
VKNNAKKRKM
280
FESFIESVPL
290
FKSLEMSERM
300
KIVDVIGEKI
310
YKDGERIITQ
320
GEKADSFYII
330
ESGEVSILIR
340
SKTKTNKNGG
350
NQEVEIAHCH
360
KGQYFGELAL
370
VTNKPRAASA
380
YAVGDVKCLV
390
MDVQAFERLL
400
GPCMDIMKRN
410
ISHYEEQLVK
420
MFGSNLDLLD
PGQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031588 | nucleotide-activated protein kinase complex |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.